Hi Dr. Aussie Neil! I am pleased to write to you once again about my test result. As i previously indicated, a year ago i was diagnosed with CLL Rai Stage II B and put on R-CVP chemoimmunoterapy and now 4 months since i took the last 6th infusion of 6 cycles recommended for my treatment. But still i have swollen sub-mandibular lymph nodes and recently increased size of my neck on both sides. I do have drenching night sweats as if my shirt is socked in water and still i have mild spleenomegally. previously my treatment regimen was initiated prior to conducting cytogenetic tests to identify genomic aberrations related to my CLL cases. I recently got my blood sample tested abroad and the result showed that the cells analyzeby FISH Panel test were negative for deletions of 13q14.3, TP53( 17p13) and ATM(11q22.3). But the result showed positive results for trisomy 12 with negative result of the IGH/CCND1 translocation. would you kindly give me your expert suggestion on what my treatment option would be for this faulty trisomy 12 chromosome with negative IGH/CCND1 translocation. I would be very grateful as usual for your help.