cll and Fenbendazole

[tbeau]

My friend has CLL and i have read so much on Fenbendazole joe Tippens protocole having used it on my husband im wondering if it could be good for my friend with cll?

[cajunjeff]

The answer is no.

[caven]

The active ingredient, Fenbendazole, is a canine dewormer for dogs older than six-months (tapeworm, whipworm, roundworm & hookworm parasites).

Do you bark? Have you worms? Is your husband a canine? If the answer is NO, then this medicine is not for you or any family members (except perhaps for Fido)!

Caven

[MsLockYourPosts Passed Volunteer]

The best thing that you can do for your friend is to not make suggestions about her care. Most of us can post lists of things "friends" tried to talk us into. Your friend needs a good doctor who is very knowledgeable about CLL to make any and all treatment decisions, and friends who offer support rather than treatment advice. I wrote off one good friend who just couldn't accept that. Noni Juice was going to cure all of my health issues and CLL doctors were going to kill me with chemo. I had enough going on without that!

[81ue]

Looks like it was researched in 2014

ncbi.nlm.nih.gov/pmc/articl...

and in 2008

ncbi.nlm.nih.gov/pmc/articl...

[AussieNeil Administrator in reply to 81ue]

You've referenced the 2014 article twice, which reported on in vitro mouse model studies - the lowest level of confidence, with confidence of an effect improving with in vivo mouse model, then in vitro and finally in vivo human studies. To save others looking, note the conclusion: "These studies provided no evidence that fenbendazole would have value in cancer therapy, but suggested that this general class of compounds merits further investigation."

Neil

[81ue in reply to AussieNeil]

Meant to cut and paste

ncbi.nlm.nih.gov/pmc/articl...

from 2008

Those were the only 2 that came up

[AussieNeil Administrator in reply to 81ue]

Interestingly, this older in vivo rodent study uses the B-lymphocyte P493-6 cell line, which was established from a clone of the EREB2-5 Epstein Barr Virus positive lymphoblastoid cell line. Of concern from that paper, "Fenbendazole has had immunomodulatory effects in sheep and mice18 and stimulated proliferation of T and B cells in healthy mice." One tumour also was reported as growing in the study.

Thanks for finding these interesting studies.

Neil

[BlueEyes90 in reply to AussieNeil]

You may want to look again at this study published in nature, it turns out fenbendazole acts by three seperate pathways. nature.com/articles/s41598-...

[AussieNeil Administrator in reply to BlueEyes90]

Sorry, there's nothing in that 2018 paper that indicates fenbendazole could be useful for the treatment of CLL. No lymphoma cells lines were studied, with the only human cancer research being done on lung cancer (NSCLC) cell "in vitro" observations - not "in vivo" - people actually taking fenbendazole. The oral treatment studies were on mice.

Also the primary pathway of interest in that research is glucose uptake, but CLL cells preferentially metabolise fats, not glucosehealthunlocked.com/cllsuppo...

Neil

[Ellieoak]

Dear Tbeau, NO!!! Sincerely, Anna

[frostbiteapple]

There is a phase 1 study using a sister drug Mebendazole for brain cancer:cancer.gov/about-cancer/tre...

[BlueEyes90]

Here is an interesting article, outlining the multiple anticancer pathways that fenbendazole exerts on the body. It was published in nature..nature.com/articles/s41598-...

[AussieNeil Administrator in reply to BlueEyes90]

BlueEyes, do you have a diagnosis of CLL or lung cancer? You've replied three times to a 4 year old post, referencing a 2018 study which mainly focuses on the effect of fenbendazole, a canine dewormer for dogs, on a range of Non Small-Cell Lung cancer cell lines. Per my reply to your earlier reply to me here, there's nothing in that Nature paper that's relevant to CLL, a B cell Non-Hodgkin's Lymphoma healthunlocked.com/cllsuppo...

Neil