Acalabrutinib Ventoclax

[Yidarmy69]

Acalabrutinib after 2 cycles today is the day I start my Ventoclax cycle.So far my results have been brilliant on Acalabrutinib I am hoping for the same on my new path on this second part of my trial I will still be taking Acalabrutinib daily

[MystyUK]

Good luck, hope you have very positive results with little side effects. Looking forward to hearing how it goes🤞🙏

[Yidarmy69 in reply to MystyUK]

Thank you very much

[Yidarmy69 in reply to MystyUK]

Hi just read your post brilliant news for you it is unbelievable how quickly the lumps disappear I hope you have little or no side effects like I have . So far I’m ok on Venetoclax fingers crossed it stays the same

[MystyUK in reply to Yidarmy69]

I'm feeling pretty good considering, I'm pleased to hear your venetoclax hasn't caused you any significant problems, here's hoping you continue to feel as good as you are😊🙏

[Yidarmy69 in reply to MystyUK]

Cheers

[Root65]

Great news, good luck with the next stage

[Yidarmy69 in reply to Root65]

Thank you

[Canuck901]

Just a question ? What duration is a cycle ? 4!weeks ? How many cycles of. Venetoclax will you have ? What are your markers ?

[Yidarmy69 in reply to Canuck901]

Hi Ventoclax cycle is weekly but increased for 4 weeks my markers are ,Haem 134 WBC 18.4 platelets 184 RBC 4.51 Haematocrit 0.444 mean cell volume 98.4 mean cell haemogoblin 29.7 MCHC 302 Neutrophils 4.0 lymphocytes 13.3 monocytes 0.8 hope you understand all this

[Canuck901 in reply to Yidarmy69]

How about markers like unmutated ? Mutated ? TP54 or any q del ?

[Yidarmy69 in reply to Canuck901]

I was diagnosed in December 2018 with Unmutated 1gvh del11q hope this helps

[may04cll]

thanks for participating in this trial , this is the 1st time i'm hearing of these two drugs together please keep us informed of your progress .

[Yidarmy69 in reply to may04cll]

I definitely will day 2 of Ventoclax then after 7 days does is increased weekly for 4 weeks until I reach maximum dose

[Yidarmy69 in reply to may04cll]

Hi had a CT scan last week results show my noades are normal size bloods all good dr tells me I’m in remission now but got to continue drugs for about 10 months

[Yidarmy69]

I will keep everyone informed taken tablets now have to wait for bloods then go back tomorrow for more bloods to make sure kidneys are coping with the cells being flushe d out

[Canuck901 in reply to Yidarmy69]

Yes that’s standard procedure when taking Venetoclax to avoid tumour lysis

[Stuff427]

I just read about your journey. I'm very interested in this combination as I am on acalabrutinib now.

Do you have an update that you can share?

[Yidarmy69]

Hi I was diagnosed in October 18 after routine blood test a year later I started treatment on the Ace Cll 311 trial my bloods where all very high not sure of numbers but if you want I will try and find out started Acalabrutinib in October 19 no adverse effects slight headache for a day at the same time I was given aciclovir 400mg twice a day + Co trimoxazole twice a day Monday Wednesday and Friday my noades which were noticeable on my neck disappeared within days a month later venetaclax was added in in stages 100 then 200 300 then 400mg in again no adverse effect on me in may / June my bloods are all in the normal range my dr has told me I’m in remission just waiting for BMB results these are sent to America for testing still waiting to hear I am very lucky to be on this brilliant trial hope this helps please feel free to ask if you want to know anything else cheers 🍻 keep safe

[Stuff427 in reply to Yidarmy69]

Thanks Yidarmy

m 60 days in on acalabrutinib, wonderful drug only bloating issues that resolved themselves. WBC started at 240 now 139. All is good, however I always believed that a multi-drug approach would be best. My questions for you is, when you started Venetoclax were you hospitalized? What were your WBC and Lympocytes at that time? Last question as of now have your neutrophil counts been affected, (have they dropped)?

Thanks

[Yidarmy69 in reply to Stuff427]

During venetaclax ramp up I was deemed low risk of TLS so didn’t need to be hospitalised I went home after blood test venetaclax tablets then went back 6 hrs later for another blood test as for WBC I will try and find out at my next visit in a few weeks if I find out before I will let you know cheers

[Lily_Pad_Master]

I went MRD- after seven months on Acalabrutinib, Obinutuzumab, and Venetoclax. I predict great results for you!!

[Yidarmy69 in reply to Lily_Pad_Master]

Thank you still waiting for BMB results I will post them as soon as I get them