U-MRD

[bkoffman]

Hi,

The role of undetectable Minimal residual disease (U-MRD) in CLL is evolving and becoming increasingly important. Please see my interview with Dr. Wierda on this topic from ASH AT go2l.ink/MRD and I will be on a panel discussing it at EHA in Amsterdam. It would great if you can join me.

Stay strong,

Brian Koffman

[Justasheet1]

I’ll meet you there Doc but only if you buy, I’ll fly. Just kidding. I wish I could meet up with you. However, I will see Dr Wierda in a couple of months. I’ll ask him about this.

Jeff

[bkoffman CLL CURE Hero in reply to Justasheet1]

It sounds like a lot of fun but all this flying gets old fast. Not complaining. I am blessed to have the opportunity, but it is not all glory.

[Justasheet1 in reply to bkoffman]

Doc,

Sounds like you need to go on another Safari. I remember you writing about it on your blog.

Thanks for all you do. It definitely has impacted my life and the decisions that I have made. Thanks for

Cllsociety.org

Jeff

[Sushibruno in reply to Justasheet1]

Let us know what Dr. Wierda said Jeff.

[PlanetaryKim]

Thanks for this article Brian. Very helpful.

[bkoffman CLL CURE Hero in reply to PlanetaryKim]

Thanks.

[81ue]

How is MRD status reflected /noted in the flow cytometry? Is it just "MRD"? Or does it give the # of cells in 10,000 that are cancerous?

If I don't see a "MRD" notation that means I'm not even near there or that it wasn't tested?

[bkoffman CLL CURE Hero]

If CLL cells are seen, you are not U-MRD- It is usually ordered by flow cytometry. The notation might be no CLL cells seen and it might list the number checked.

[jijic]

When is EHA in Amsterdam?

[bkoffman CLL CURE Hero in reply to jijic]

June 13-17

[Sushibruno]

Dr. Koffman how are you doing after your car-t treatment? How often do u go see your cll doc? and what are your blood results? How are you feeling overall?

[bkoffman CLL CURE Hero in reply to Sushibruno]

All good. See my doc every 3-6 months. Blood tests are near normal with ALC<1. Get IVIG every 6-7 weeks.

[Sushibruno in reply to bkoffman]

Thank you Dr. Koffman for your prompt response. Happy to hear you're doing well👍.

[J_88 in reply to bkoffman]

What is the IVIG for Brian?

[bkoffman CLL CURE Hero in reply to J_88]

Intravenous immunoglobulin, a pooled blood product, as I have no B cell lineage to make my own antibodies. I am dependent on the generosity of others.

[Benlewis in reply to bkoffman]

So Car-t treatment leaves a person with no ability to make antibodies? Is this a permanent situation?

[AussieNeil Partner Administrator in reply to Benlewis]

It is as long as the CAR-T cells survive and keep killing B-cells. There needs to be some way of turning off CAR-T cells after the CLL cells have been eliminated.

Neil

[Name-1]

Best wishes and greeting,Dr.Koffman!

Olga

[AllanJardin]

Thank you very much Dr Brian.

[johnl]

Back when FCR was king, UMRD was associated with a long remission, but those patients were also all mutated IGHV. Today with Venetoclax unmutated patients are reaching UMRD ( I hope to soon be one of them) it's going to be interesting to see if that association between UMRD and long remissions still holds up with these unmutated IGHV patients. I get an impression most people assume this association will hold up, but I'm not so sure.

john

[Smakwater in reply to johnl]

In addition to the new agent successes for those of us who are unmutated, It would also be good to see some advances in richters treatment.

[bkoffman CLL CURE Hero in reply to Smakwater]

RT is a big unmet need.

[bkoffman CLL CURE Hero]

I am digging into what data there is on that question.

[avzuclav]

Reminds me of this healthunlocked.com/cllsuppo...