I am b-pll. i am p17 deletion and p53 mutated. I get treated like advanced CLL because there are so few b-pll patients not enough to get drug indications approved.
Conventional pre novel drug era drugs are mostly resistant.
i have been on Imbruvica for 3 months and have had dramatic improvement. I also realize that with my markers there is no expectation of a long term on imbruvica.
I am considering asking my doctor to add a drug to my imbruvica.
the more knowledgable of you might have opinion.
If you have a choice of what to add, I would go with venetoclax. I am hoping to find a way to add it to the ibrutinib I am taking.
They are both good choices, indeed adding both wouldn't be a bad idea either.
There are a lot of ongoing clinical trials involving ibrutinib/venetoclax/gazyva in various combinations and from all I have read, most of the early results from these trials has been very encouraging.
I like the idea of adding venetoclax because it seems to me to be the most powerful of the three and most likely to mop up whatever cll cells ibrutinib is not killing.
I think for me there might be an approval issue adding venetoclax, since ibrutinib is working well on its own. Hopefully venetoclax gets a broader approval soon. jeff