I See very little about levels of Immunology . Mine have been going down steadily especially my IGg levels. Right now my MY IGg is 265 down from 335 4 mnths ago. IGa is 29 and IGm is 23. I get small infections every now and again. Just finished canker sores in my mouth. Can anybody comment of low levels .
IGg: I See very little about levels of... - CLL Support
IGg
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I started getting IVIG after my IGG levels fell below 400. I think that's the level you need to be to get approved in the US. I had been getting them monthly until recently when I had to start rituxan and idelalisib. I will be getting them again in a few weeks.
My allergy doctor had said that when you get below 300 to 400, it's not a question of if you will get sick, but when you will get sick.
I felt so much better after starting them. I've had much less fatigue and just felt better in general. My IGG was 377 when I started and it went up to the 900s after a few months.
How often should they be checking the IGg levels? Mine have only been checked at my initial diagnosis
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immunoglobulin and neutrophil levels are regularly discussed due to the major impact they have on our immunity. Development of hypogammaglobulinemia (low immunoglobulin counts) is a common symptom of CLL, because CLL cells suppress T-cell function (needed to respond to pathogens and plasma cell counts. (Plasma cells are mature B-cells that churn out immunoglobulins.)
Immunoglobulin production is part of our humoral immunity: en.wikipedia.org/wiki/Humor...
Here are the IgG and IVIG search results for open posts:
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If/when Search is expanded to include Locked posts, you'll find many more.
Low levels without significant infections are not considered a valid reason for starting either IVIG or subcutaneous IgG infusions. The requirement is IgG below a trigger level (depends on the country) and recent serious infections, generally requiring hospitalisation. Only IgG can be supplemented by infusions - but increased levels of IgG can somewhat cover the impact of the lower igA and IgM counts.
SherriD , how often your immunoglobulins are checked will depend on how low they were at diagnosis and how slowly they are changing. (If they do begin to fall - and again it's a trend that is looked for, as they can rebound, then it's generally a very gradual process is my understanding). My IgG and IgM were below the reference range at diagnosis and my specialist checked them every 6 to 12 months until I started monthly IVIG, when they were initially checked monthly.
Neil