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CLL Support Association
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Modified venetoclax ramp up

Has anyone been put on a modified (rapid ramp up) venetoclax plan? Edit: My Dad has completed the first full week on 20mg but will now cut the 50mg week short to 4 days -proceeding to 100mg on the 5th day.

Does anyone have experience with a similar or different modified dose ramp up? Thanks.

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I have the meds but specialist suggested I wait a couple weeks since I’ve been sick, I’m now much better and will see him Tuesday. Could you share the new modified ramp up?

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Hi MartiP2009 thanks for your msg. I hope you’re feeling better soon. I’ve edited my initial post thank you :)

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Jay, if you will look just to the right of your post (if on desk/computer) or at bottom of whatever other device you may be on, you will see

Related Posts--a list of similar topic that have been posted giving members experiences and other info re: venetoclax.

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Thank you cllady01 for your message. I’ve looked through similar posts but wanted to post in case I had missed something or someone might have had some recent experience they might like to share.

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Thanks for sharing

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Hi jayeo,

When I looked back at your original posting I found this information: My Dad was diagnosed with TPLL in 2013 so you are trying to transfer our experience with Venetoclax on CLL to another NHL - TPLL

I think our best advice is to make certain your Dad is closely monitored by a expert doctor familiar with Venetoclax, after each dose increase. He may need blood draws and "STAT" test results before each dose increase and at 4-6 hours, 8-12 hours and 24 hours after the dose increase.

In my case I was an inpatient for 30 hours for the 20 mg and 50 mg doses, and when the 24 hour results were interpreted, then I went home to take the remaining 6 doses.

I took the increase to 100 mg, 200 mg and 400 mg, as an outpatient with a much more relaxed schedule of blood draws, so I assume that your doctor and mine saw the biggest risks at 20mg and 50 mg.

I assume your Dad's doctor has a specific reason to shorten the time between the 50 mg and 100 mg dose.

Len

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Hi lankisterguy, thanks for your message. I appreciate your advice but I am not trying to transfer CLL experience to my Dad’s case. I am sure I had seen another person’s post about tpll here hence thought it would be okay to post here too in the hope of getting a further general understanding of venetoclax as I have not yet come

across a similar medium/forum for tpll. The same protocol of ramp up has been initially applied in my Dad’s instance and I was hoping that nothing has been missed. I understand these are completely different leukemias. Appreciate your message, info and advice.

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Hi jaye0,

I'm sorry if you were upset or offended by my mentioning the TPLL and the experience transfer, I was not implying that your request was inappropriate or unwelcome. I was only trying to make all the background info available to other readers.

I am very happy to share my experience with you- as you can see from my reply. I hope it is helpful to you and your dad. And please ask if there are other details we can share.

Len

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I know I saw someone post about the faster ramp up somewhere - maybe on cllforum.com/, and maybe at Ohio State. You might try posting your question there.

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