ATM

[jaypax]

Hi.

I had an appointment today with my haematologist and was told that I have ATM deletion. Does anyone have any information on this? The proposed treatment is Ibrutinib commencing in the next couple of weeks. I would be grateful for any information on this.

Best wishes

Jeff P

[Hidden]

You should ask your Hematologist for specifics but generally this refers to an 11q deletion of the ataxia-telangiectasia-mutated gene.

Scott

[jaypax in reply to Hidden]

Thank you Scott. I am reading up and have another appointment in two weeks when I will ask my haematologist for more information. Jeff

[Cllcanada Top Poster CURE Hero]

Good page here.. click the blue bars on the website to show more...

ghr.nlm.nih.gov/gene/ATM#lo...

ATM is the cell cycle quality control inspector... you have two, so there is some cell checking being done.. but invariably malformed cells will get past the ATM department...

Imbruvica (ibrutinib) is a good choice of treatment...

~chris

[fapumpkin]

I was told 3 months ago that I also have ATM deletion and the first treatment that I have been treated with has been the combination of rituximab (1monthly infusion over 6 months, 2 years ago) and Ibrutinib for the last 2 years, as part of the Flair clinical trial in the UK. I will be asking my Consultant next week for more information and what this means in relation to Cll, I have been living with the diagnosis for over 12 years having been diagnosed aged 42.

[jaypax in reply to fapumpkin]

Hi. Thanks for your reply - interesting combination of rituximab and ibutrinib. I was treated 3 years ago with bendamustine & rituximab but only had 2 years remission. Fortunately my LHA has funding for Ibutrinib, so starting in 2 weeks and see how it goes. Am trying to come to terms with it at the moment. Not an easy task! Best wishes to you in your journey!

[Bramleys]

Hope all goes well for both of you.

[jaypax]

Hi. Thanks for your message. Fingers crossed!

Jeff