I have been off ibrutinib for 6 weeks because of adverse reaction. I have recently re-started (2 weeks) and have an appointment with my hemo/oncologist next month. I was wondering if anyone else has been off treatment and then restarted. Did the ibrutinib continue to work for you? I started with a WBC 130 and HGB of 61(increased to 88 by transfusion) in December 2017.Initially Ibrutinib very quickly knocked my counts to WBC 8 and melted the nodes under my chin. Hope to be able to continue on ibrutinib as chemo is out of the picture for me because I have had chemo and radiation for colonrectal cancer and cannot risk any further damage.