Best day time for Ibrutinib
Next week I will receive the prescription for Ibrutinib and I'm interested in knowing when is better moment to take it.
Thanking for all your comments,
Others may have an opinion regarding side effects and time of treatment, but for me it was what would fit best into my schedule. It has to be on an empty stomach and no food for one or two hours. First thing in the morning worked for me - no scheduling issues.
The Morning didn't work for me because I need to eat something and drink coffee. I take at night before bed. I set a daily reminder on my iPhone so I never forget! I think it was better on my stomach
Sorry VaCooper, no offense,😀 but the doctors are all over the page on this one. I am on a trial so I have to take it when they tell me to. I was told to take it in the morning on an empty stomach, but we do not have to wait to eat. As I told some one yesterday, I actually eat a half of banana while swallowing the pills with about 4 oz of water per pill. As soon as the pills are down I have my coffee and breakfast. This schedule was approved by the trial. Each person is different. Unless you are on a trial, you could probably take them anytime you want as long as you take them at the same time every day. Many people will take them one way and then change to another to combat a side effect, etc. I would ask my doctor and then decide what works best for you.
None taken! Certainly easier if you can eat right away.
I tried different times. The best for me was at night, before going to bed, 2 hours at least after dinner.
Ibrutinib is at its peak 6-7 hours after intake , which is best at night when there is no food digestion.
If you take it otherwise it might cause you diarreah and other side effects because IB has to be taken on an empty stomach.
I too am on a trial, I was told to take mine at teatime 30mins before food, on the information leaflet it says 30mins before or 2 hours after, have had no stomach issues while using it, Terry
Thank you all for your answers !
Yes, I know everyone is different and very important is the med.indication ,too. But,we'll see ...
Best wishes to you,
Thank you very much ,G, for your detailed informations. I belive that its are importants for us.
I think Gene7591 has misinterpreted the data, taken with food accelerates the speed of Ibrutinib reaching peak in the blood. But since it lasts 6-8 hours in the blood and irreversibly binds to the BTK receptors of every CLL clone it comes in contact with, the speed does not matter. Ibrutinib is not absorbed into your body, it stays in your blood until it finds BTK receptors or is expelled by your kidneys
So the experiened CLL experts advise taking it when side effects are least. Many find the least at night on emty stomachs. Others prefer daytime. Consistancy and not missing doses is more important than the with food vs empty stomach, IMO
As with so many... all different. I was only told... be consistent when you take it each day. I take mine about an hour or so after breakfast. In that I drink several cups of coffee ( 8 or so ) I take only a moderate dose of water with the pills. An hour or so later I start on my daily goal of 3 qts of water. Some of which is mixed lightly with bourbon during cocktail hour. Egads...yes I still enjoy my cocktails and again yesterday my blood numbers are nearly perfect.
I was told...no grapefruit ( I hate grapefruit so no big deal ) and no Orange marmalade. Now that was and is a real bad thing because I just love marmalade. But I'm roughing it out.
I second lankisterguy's (Len's) response. With a half-life of only 4-6 hours, it's not around too long, so take it when your side-effects are the least noticeable. For me, that was at bedtime. I guess I slept through the worst side-effects.
I take mine before bed. I have tired different times and this seems to be the best.
Fatigue while I sleep and does not interact with food - hopefully,
I've been taking Ibrutinib for eight months 420MG (three pills daily evening before I go to bed). Here is my experience:
- I'm now in remission as of last week. Feel much better but I think I'm about 80%.
- When I started Ibrutinib it gave me severe acid stomach, my GP had me start taking the Ibrutinib about 30 minutes before bed with about a quart of water. This works much better, but I'm taking a strong prescription medication for acid stomach and I take at least 1 to 2 OTC anti-acids daily.
- The tips of my fingers, lips and heels are chapped. I continually apply a good healing lotion pm my heels and hands. For my lips a use chap stick.
I'm thankful for my doctor's, I'm alive and the life I live.
Thank you very much for this detailed reply!
Been on imbruvica about 18 months , only side effects are sore ankles and top of feet also if I take tabs. Late at night causes weird dreams,so I take them 6pm every day ..cheers
I started taking my dose 420mg at night and for first 6-7 weeks it was fine but next three weeks I had severe Insomnia and doctor recommend I try taking during day time and see if it helps. It did but not really sure my problem was with the drug could have just been other anxiety but it has stopped and sleeping well again
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