New Practical Approaches to Chemotherapy-Induced Neuropathic Pain: Prevention, Assessment, and Treatment

New Practical Approaches to Chemotherapy-Induced Neuropathic Pain: Prevention, Assessment, and Treatment

'Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most disabling and demoralizing problems that arise for cancer survivors. When investigating symptoms of numbness, tingling, or pain in the extremities, it is critical to determine whether the problem is neuropathic, somatic, or mixed. If the diagnosis is CIPN, it is important to weigh the potential benefits and harms of possible treatment options, and to devise an evidence-based multimodality treatment program.'

Article review: Chemotherapy-Induced Peripheral Neuropathy: A Challenge for Clinicians

'Chemotherapy-induced peripheral neuropathy (CIPN) is a serious yet common side effect of cancer treatment. This devastating complication, which typically manifests as tingling and numbness in the hands and feet, has an enormous influence on patients’ quality of life. Patients with CIPN are often so disabled that they cannot complete simple tasks such as buttoning a shirt, walking normally, or signing their name. Unfortunately, the pathophysiology underlying CIPN remains unclear...'

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5 Replies

  • I'm a wobbling example... on the debilitation scale CIPN is number one followed very closely by Post Herpatic Neuropathy, PHN... of shingles...

    In my case CIPN did all the things that are mentioned, but also destroyed the positional feed back loop on my right side... so I can't judge a stair step... I must watch my foot be placed on the step in real time, and even then there is no way of knowing it it is securely planted... add to this Foot Drop.. aka Drop Foot... 😜and walking becomes somewhat tentative... 👣

    What's the flower Neil, it is a wonderful colour...

  • That's tough. I have pain all over the place sometimes more than others but can't survive reasonably without physio twice a week? I have to say the level of effort enthusiasm and dedication u put into this site would not ever betray your challenges. bravo 👏

  • It's a zygocactus which was struggling a few months ago due to some competition in its pot from a rather pretty weed. It came good when I removed the weed just in time for it to develop its beautiful blooms. There's a range of cultivars with different flower colours and variations in appearance. They are pretty hardy.

  • This I get in my fingers and hands, can still do most things but a extra difficulty I could do without. I find wearing gloves and keeping them warm helps. Just have to be more careful to try and not drop things ot to get a good grip.


  • I live barefoot as much as possible because I can feel the ground better. I won't drive with shoes on. My neuropathy has improved some over the years - not severe now but stubbing my foot on the ground, resulting in a few really good falls, convinced me to keep a pair or two of shoes in the car for the times I rush out the door in a hurry. I only once arrived at my destination with no shoes - fortunately at the vets where they have known me for about 30 years. This wouldn't work very well in snow country.

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