Anybody 13q deleted and unmutaded

[ikahan]

That's what we know so far about my husband's CLL ,diagnosed 2.5 years ago. Thanks,Ileana

[Cllcanada Top Poster CURE Hero]

Dr. Sharman has a lot on 13q and various prognostic indicators... there is a lot more now than FISH that impacts CLL.

cll-nhl.com/2012/12/new-cll...

[neurodervish]

Hi Ileana,

13q is the most common and also has the most favorable outcome. The unmutated status is the downside. Dr. Sharman has been quoted as saying something like '13q is the break pedal on the disease, but unmutated is the gas pedal.' I would begin with the link CllCanada (Chris) has posted, as it delves into the issue of mutation status. Also, here's a link to a 3-part blog post Dr. Sharman did about 13q: cll-nhl.com/search/label/13q (start at the bottom of the page)

Keep in mind that he wrote these posts in 2012 and that there have been tremendous advances in the understanding of CLL since (especially in the availability of new treatments).

[ikahan in reply to neurodervish]

Thank you neurodervish for giving me Dr. Sharman's analogies for the two CLL markers. I will use them when I have to explain to other people about my husband's CLL.