Although the article uses B-cell acute lymphoblastic leukemia as an example for morphing the cancer cells into healthy, functional macrophages, the fact that CLL/SLL is also comprised of immature B cells, might work for us too. In CLL/SLL, I am afraid there would be many more problems to overcome given the variety of clones to mention only one but in principle this is an intriguing approach that uses the cancer's own cell progeny to attack itself. Seppuku or turncoats, either way works for me. That's the kind of poetic justice in a therapy development I could really enjoy.
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