I am celebrating an anniversary of sorts. On this day, exactly three years ago at the time of my sending this post, I swallowed my first capsules of Imbruvica/Ibrutinib which was then only called PCI-32765 in a Phase Ib Clinical Trial for Relapsed or Refractory patients at OSU under the care of Dr. John Byrd.
I continue to be in a remission hovering very close to a CR (Complete Remission) if not possibly in a CR since my last monitoring in late April. The only side effect that hangs on is brittle nails that rip and break easily. If any members are contemplating getting Ibrutinib/Imbruvica and are worried by recent postings of a possible connection to cataracts I would have to say that it would be a very rare condition and not directly related to Ibru/Imbru. If anyone might have been susceptible to eye damage, I tried out for the role because I had a very nasty dry eye side effect early on in the trial for which I was almost pulled off the Clinical Trial. I was put on a Cyclosporin based eye drop and the condition persisted for months and eventually resolved where I have no need for even ordinary artificial tears. Recent eye exam confirms a same size cataract noticed prior to my CLL Diagnosis in 2006.
My PM (pacemaker) has been keeping me free of arrhythmias so far and basically I would not know I had cancer if not for the daily reminder of taking the two Ibru capsules.
I have not been monitoring the computer or emails for awhile due primarily to health issues with my wife and apologize for not getting back to any inquiries. It may be two weeks before I can get caught up.
Because we are all wanting to help ourselves, I found an intriguing study involving fasting with chemo. This study is suggestive only and was conducted with very few subjects. I had been a once a year faster for six days every summer prior to my diagnosis. I have been interested in the effects of Autophagy both from fasting and drug inducement.
Since many of our community members will not have access to the new kinase inhibitors (Ibru/Imbru Idelalisib) and must be treated with chemo I thought this case history study on fasting might be worth reading and discussing with your respective Docs.
Wishes for finding a good path to all.