Has anyone any experience of Ofatumumab ?

[isambard]

After two months in hospital and neutrophils at zero my consultant put me on Ofatumumab . My neutrophils immediately returned. I am at home now after five lots of the drug and continuing as an outpatient. Apparently the drug isn't very effective for CLL so what can I expect long term ?

[Cllcanada Top Poster CURE Hero]

Nobody can answer your question, we are all different. You appear to have had a good response so that is what is important at the moment.

[bkoffman CLL CURE Hero]

In your case, the Ofa might have worked by clearing space in the marrow for the neut precursors, but it also might have turned off some auto-immune process attacking the neuts in the blood. You will never know. Some patients do very well on it in terms of reducing their CLL. We are all so different. Stay strong.

[UKfulloflife]

I am on the Rialto trial and have had 4 cycles of Ofatumumab and Bendamustine. I've had to give up because of bad reactions to the Bendamustine but the results are being described as fantastic. Lymphacites(? spelling!) now 0.6 against 203 pre treatment. My consultant says that I can expect 3 - 4 years without further issues, so I think it is pretty effective! But as said above, we are all different.

[chrismac]

apologies isambard,i am new to this and have noinfo for you sorry chrismac

[springfield2]

Hi Isambard

Having recently finished a 6 month Rialto Trial which uses Ofatumumbad &Bendamustine with excellent results

and now in remission. Good luck with your future treatment

[isambard]

Thank you for all your replies . I am doing well after six infusions. Two more and then four weeks off, followed by monthly treatment, I think. I'm not having the chemo bit ( Bendamustine) probably because of P17 deletion. )