Dr Sharman on Monoclonal B Lymphocytosis (MBL), a sometimes precursor to CLL

Dr Sharman on Monoclonal B Lymphocytosis (MBL), a sometimes precursor to CLL

In another informative and easy to understand blog, Dr Sharman discusses MBL, what it means to have it and how it is differentiated from CLL. This requires an explanation of cluster of differentiation (CD) markers and how Flow Cytometry is used to tell apart the different lymphomas and leukaemias by looking for tell tale CD marker patterns.

Anyone that has been recently diagnosed with a high lymphocyte count and is awaiting further testing will find this blog by Dr Sharman extremely relevant and helpful. At the end of his blog, he discusses his reasoning behind follow-up times for patients with abnormal lymphocyte blood counts.


There are some good references in this blog too, including:

- A guideline paper for MBL (Dr Sharman says that such papers are uncommon)

- How to read a flow cytometry or FISH report (50 minute video)

- How to understand your complete blood count (CBC), which I've added below

National Institutes of Health Education Paper on understanding your CBC


This paper also includes helpful information on how to live with neutropenia (low neutrophils), anaemia (low blood iron) and thrombocytopenia (low platelets).


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  • Just wanted to mention, that the late Dr. Terry Hamblin was fairly involved in the early days of MBL, and his blog has a number of articles on this topic. May be of interest...


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