Chromothripsis is the phenomenon by which thousands of clustered chromosomal rearrangements occur in localised and confined genomic regions in one massive genomic rearrangement during a single catastrophic event in the cells' history.
A quote from this study....still a work in progress.
'We confirmed the single catastrophic model for chromothripsis, but we showed that it
appeared years after the CLL diagnosis, rejecting a hypothetic role in the tumor
initiation. Our data suggest that chromothripsis might have been the consequence of
previous alterations expanded from an early leukemia cell, which would have led to
chromosome instability associated with defects in DNA repair.
The complex rearrangements of chromothripsis added on a previous tumor cell carrying expanded alterations might have conferred a selective advantage to the sub clonal population increasing its malignancy, providing a more aggressive CLL phenotype.'
Clemastine (Tavegyl), an over-the-counter drug, found to be effective at inducing LMP and cell death
Long-Term Ibrutinib Therapy Reverses CD8+ T Cell Exhaustion in B Cell CLL
in our discussions about cause of CLL 
