Search
Search
About
Log in
Join
Experiences with
Chlorambucil
Posts
Communities
110 public posts
Filter results
Median PFS for FCR treated CLL patients with IGHV-M was 14.6 years vs 4.2 years for patients with IGHV-UM. V+O and I+R look to be superior
Prior to the advent of targeted therapies, we only had chemoimmunotherapy treatments, typically BR (bendamustine+rituximab) or a very old drug
chlorambucil
to offer to most patients needing treatment.
Prior to the advent of targeted therapies, we only had chemoimmunotherapy treatments, typically BR (bendamustine+rituximab) or a very old drug
chlorambucil
to offer to most patients needing treatment.
AussieNeil
Partner
in
CLL Support
2 months ago
Anyone with AF got any experience with taking either Zanubrutinib or R&V
I was previously treated with Obinutuzumab and
Chlorambucil
for 5 sessions and this proved to be very effective as my bloods all returned to ‘normal’ very quickly and I have remained very well during and after the treatment.
I was previously treated with Obinutuzumab and
Chlorambucil
for 5 sessions and this proved to be very effective as my bloods all returned to ‘normal’ very quickly and I have remained very well during and after the treatment.
Ageon
in
CLL Support
8 months ago
Chronic Lymphocytic Leukemia Therapy Guided by Measurable Residual Disease
[/i] [i]However, only trends toward improvement in overall survival have been seen as compared with
chlorambucil
and obinutuzumab. These approaches are based on the principle that “one size fits all,” and therapy is not individualized on the basis of response.
[/i] [i]However, only trends toward improvement in overall survival have been seen as compared with
chlorambucil
and obinutuzumab. These approaches are based on the principle that “one size fits all,” and therapy is not individualized on the basis of response.
Jm954
Administrator
in
CLL Support
9 months ago
Want to take advantage of all our features? Just log in!
Log in
or
Join
Advise on CLL Treatment Options - UK
This consisted of 5 cycles of Obinutuzumab +
chlorambucil
which very successfully addressed my CLL and returned all my bloods to normal very quickly. During this 4 year period I haven't experienced any problems at all.
This consisted of 5 cycles of Obinutuzumab +
chlorambucil
which very successfully addressed my CLL and returned all my bloods to normal very quickly. During this 4 year period I haven't experienced any problems at all.
Ageon
in
CLL Support
10 months ago
Introduction & a quick question...
My doctor initially had me take a low dose of (50% normal)
Chlorambucil
for a few weeks to bring down the lymphocyte count into the low 100s. I have had my first two weeks of Obin (100/900 mg & 1000 mg) and had a question which I haven't been able to find answered online anywhere else.
My doctor initially had me take a low dose of (50% normal)
Chlorambucil
for a few weeks to bring down the lymphocyte count into the low 100s. I have had my first two weeks of Obin (100/900 mg & 1000 mg) and had a question which I haven't been able to find answered online anywhere else.
kbondale
in
CLL Support
11 months ago
CLL and Hyperthroid
I was treated for CLL in 2018 -
chlorambucil
and Gazyvaro. No problems at all until last month a random blood test indicated an over active thyroid, for which I am now taking medication. I understand that both conditions relate to the immune system.
I was treated for CLL in 2018 -
chlorambucil
and Gazyvaro. No problems at all until last month a random blood test indicated an over active thyroid, for which I am now taking medication. I understand that both conditions relate to the immune system.
Hidden
in
CLL Support
1 year ago
Zanubrutinib and water intake and sodium level
I was diagnosed in 1998 and given a small amount of prednisone and
chlorambucil
and have received nothing since except ivig which started in June2021 due to infections.
I was diagnosed in 1998 and given a small amount of prednisone and
chlorambucil
and have received nothing since except ivig which started in June2021 due to infections.
Bethsaida
in
CLL Support
1 year ago
estrogen therapy
Due to enlarged under arm lymph nodes and wbc of 35000 I was treated after diagnosis with what they gave at that time which was called pulse dosing of
chlorambucil
and prednisone for 4 days a month for 4 months.
Due to enlarged under arm lymph nodes and wbc of 35000 I was treated after diagnosis with what they gave at that time which was called pulse dosing of
chlorambucil
and prednisone for 4 days a month for 4 months.
Bethsaida
in
CLL Support
2 years ago
My diagnosis has changed from Lymphoprolific none nodal mantle cell lymphoma age 56 to more of a CLL at 79 years.
When lymphocytes progressed had Retuxan and
Chlorambucil
4 rounds in 2017. Count started going back up in 2021. I would be very pleased to get more knowledge of my “new” disease. Thankyou Jennifer_africa
When lymphocytes progressed had Retuxan and
Chlorambucil
4 rounds in 2017. Count started going back up in 2021. I would be very pleased to get more knowledge of my “new” disease. Thankyou Jennifer_africa
Jennifer_africa
in
CLL Support
2 years ago
Optimal Treatment Combinations in the Management of CLL/SLL Jeff Sharman, MD Provided by Clinical Care Options, LLC
In the randomized phase III CLL11 study, either obinutuzumab or rituximab was combined with
chlorambucil
compared with
chlorambucil
alone for patients with previously untreated CLL and coexisting conditions.
In the randomized phase III CLL11 study, either obinutuzumab or rituximab was combined with
chlorambucil
compared with
chlorambucil
alone for patients with previously untreated CLL and coexisting conditions.
lankisterguy
Volunteer
in
CLL Support
2 years ago
Concise summary of the treatment history of CLL from the 1950s to the present, by Dr Bruce Cheson, contributor to the iwCLL and much more
I knew
Chlorambucil
use for CLL dated back to the 1950's but I hadn't appreciated that was also the case for cyclophosphamide, (the 'C' in FCR).
I knew
Chlorambucil
use for CLL dated back to the 1950's but I hadn't appreciated that was also the case for cyclophosphamide, (the 'C' in FCR).
AussieNeil
Partner
in
CLL Support
2 years ago
Is pain to be expected with CLL?
I've enjoyed a remission of around 2 yrs following
chlorambucil
and obinutuzimab. I'd appreciate any comment or suggestions about joint pain as this has come as an unpleasant surprise.
I've enjoyed a remission of around 2 yrs following
chlorambucil
and obinutuzimab. I'd appreciate any comment or suggestions about joint pain as this has come as an unpleasant surprise.
Handley
in
CLL Support
2 years ago
Relapsed CLL: New Approaches Prolong Survival
Study participants were treated with six cycles of either venetoclax-obinutuzumab (VO) or
chlorambucil
-obinutuzumab (CO); the 4-year PFS was 74% vs. 35.4% (P < .0001) respectively.
Study participants were treated with six cycles of either venetoclax-obinutuzumab (VO) or
chlorambucil
-obinutuzumab (CO); the 4-year PFS was 74% vs. 35.4% (P < .0001) respectively.
Jm954
Administrator
in
CLL Support
1 year ago
Ibrutinib Resistance
She went through several treatments:
Chlorambucil
for 3 yrs, then Bendamustine/Rituximab (6 cycles) with remission for 1.5 yrs. Afterwards, her CLL transformed to B-PLL (pro-lymphocytic transformation) with 17p deletion so she was recommended to start on Ibrutinib (Imbruvica) from late 2019.
She went through several treatments:
Chlorambucil
for 3 yrs, then Bendamustine/Rituximab (6 cycles) with remission for 1.5 yrs. Afterwards, her CLL transformed to B-PLL (pro-lymphocytic transformation) with 17p deletion so she was recommended to start on Ibrutinib (Imbruvica) from late 2019.
Adel1
in
CLL Support
3 years ago
Frontline treatment of Chronic Lymphocytic Leukemia (CLL/SLL) in 2021
Until recently, chemoimmunotherapy regimens such as fludarabine, cyclophosphamide, and rituximab (FCR), bendamustine and rituximab, and
chlorambucil
and obinutuzumab were considered standard first-line therapy for patients with CLL.
Until recently, chemoimmunotherapy regimens such as fludarabine, cyclophosphamide, and rituximab (FCR), bendamustine and rituximab, and
chlorambucil
and obinutuzumab were considered standard first-line therapy for patients with CLL.
CLLerinOz
Administrator
in
CLL Support
3 years ago
From the CLL14 Study: Venetoclax Plus Obinutuzumab Prolongs Progression Free Survival, Not Overall Survival , in CLL
plus obinutuzumab or
chlorambucil
plus obinutuzumab.
plus obinutuzumab or
chlorambucil
plus obinutuzumab.
Jm954
Administrator
in
CLL Support
3 years ago
Frontline Ibrutinib/Venetoclax Elicits Durable Responses in CLL With Undetectable MRD
Fixed duration ibrutinib and venetoclax (I+V) versus
chlorambucil
plus obinutuzumab (CLB+O) for first-line (1L) chronic lymphocytic leukemia (CLL): primary analysis of the phase 3 GLOW study.
Fixed duration ibrutinib and venetoclax (I+V) versus
chlorambucil
plus obinutuzumab (CLB+O) for first-line (1L) chronic lymphocytic leukemia (CLL): primary analysis of the phase 3 GLOW study.
lankisterguy
Volunteer
in
CLL Support
3 years ago
Long-Term Data Showcase the Clinical Utility of Fixed-Duration Venetoclax/Obinutuzumab in Treatment-Naïve CLL
Additionally, undetectable MRD remissions were found to be deeper and more sustained with venetoclax/obinutuzumab vs
chlorambucil
/obinutuzumab in this patient population.
Additionally, undetectable MRD remissions were found to be deeper and more sustained with venetoclax/obinutuzumab vs
chlorambucil
/obinutuzumab in this patient population.
lankisterguy
Volunteer
in
CLL Support
3 years ago
AbbVie Pharm--positive phase 3 for CLL!
After a median follow-up of more than four years, patients treated with the Venclyxto/Venclexta and obinutuzumab combination continued to demonstrate longer progression free survival compared to patients on treatment with obinutuzumab and
chlorambucil
, and the risk of disease progression or death was
After a median follow-up of more than four years, patients treated with the Venclyxto/Venclexta and obinutuzumab combination continued to demonstrate longer progression free survival compared to patients on treatment with obinutuzumab and
chlorambucil
, and the risk of disease progression or death was
Vlaminck
in
CLL Support
3 years ago
News - Acalabrutinib approved for Restricted use in Scotland
[/i] Evidence presented showed that Acalabrutinib, compared with
chlorambucil
-obinutuzumab, significantly improved progression-free survival in adults with previously untreated CLL with co-morbidities. Jackie
[/i] Evidence presented showed that Acalabrutinib, compared with
chlorambucil
-obinutuzumab, significantly improved progression-free survival in adults with previously untreated CLL with co-morbidities. Jackie
Jm954
Administrator
in
CLL Support
3 years ago
1
2
...
6
Next page
Filter results
Clear filters
Posted in
All communities
CLL Support
105 results
Leukaemia Support
2 results
Behçet's UK
1 result
View top 10 communities
Sort by
Most Relevant
Newest