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Chlorambucil
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Obinutuzumab (GA101) delayed disease progression longer than MabThera/Rituxan - Roche press release on CLL11 study
chlorambucil
.
chlorambucil
.
AussieNeil
Partner
in
CLL Support
11 years ago
Halted Clinical Trial Comparing Revlimid and Chlorambucil in Patients > 65
An unexpected significant increase in deaths in the lenalidomide arm of the trial lead the FDA to stop it. But I don't believe that is the whole story and this is too good a drug to throw out. I have two posts on my blog at http://bkoffman.blogspot.com that deal with this that also have links to other
An unexpected significant increase in deaths in the lenalidomide arm of the trial lead the FDA to stop it. But I don't believe that is the whole story and this is too good a drug to throw out. I have two posts on my blog at http://bkoffman.blogspot.com that deal with this that also have links to other
bkoffman
CLL CURE Hero
in
CLL Support
11 years ago
Celgene is discontinuing Revlimid Phase III ORIGIN Trial
Celgene said that an imbalance was observed in the number of deaths in patients treated with Lenalidomide versus patients treated with
Chlorambucil
.
Celgene said that an imbalance was observed in the number of deaths in patients treated with Lenalidomide versus patients treated with
Chlorambucil
.
AussieNeil
Partner
in
CLL Support
11 years ago
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Chlorambucil may be a more reasonable choice for elderly CLL patients than fludarabine.
Interaction effects of fludarabine versus
chlorambucil
by age group showed that among patients younger than 70 years, PFS and OS was improved with fludarabine over
chlorambucil
, but not in older adults.
Interaction effects of fludarabine versus
chlorambucil
by age group showed that among patients younger than 70 years, PFS and OS was improved with fludarabine over
chlorambucil
, but not in older adults.
AussieNeil
Partner
in
CLL Support
11 years ago
Promising clinical results for new drug combination for CLL (GA101 plus Chlorambucil)
“This data shows that adding GA101 to
chlorambucil
chemotherapy can improve response and remission time for these patients.
“This data shows that adding GA101 to
chlorambucil
chemotherapy can improve response and remission time for these patients.
HAIRBEAR_UK
Administrator
in
CLL Support
11 years ago
Obinutuzumab Active in Elderly Chronic Lymphocytic Leukemia
' Adding the investigational monoclonal antibody obinutuzumab (GA101, Genentech) to
chlorambucil
in elderly patients with chronic lymphocytic leukemia (CLL) more than doubled time to disease progression in a phase 3 trial.
' Adding the investigational monoclonal antibody obinutuzumab (GA101, Genentech) to
chlorambucil
in elderly patients with chronic lymphocytic leukemia (CLL) more than doubled time to disease progression in a phase 3 trial.
Cllcanada
Top Poster CURE Hero
in
CLL Support
11 years ago
Dr Sharman begins blogging on relevant ASCO papers
GA-101 aka. obinituzumab in CLL Dr Sharman reports the big updates for this year and discovers something new from the report on the German three arm CLL11 study, in which
chlorambucil
was compared to
chlorambucil
in combination with either rituximab or GA-101.
GA-101 aka. obinituzumab in CLL Dr Sharman reports the big updates for this year and discovers something new from the report on the German three arm CLL11 study, in which
chlorambucil
was compared to
chlorambucil
in combination with either rituximab or GA-101.
AussieNeil
Partner
in
CLL Support
11 years ago
Human carcinogens to treat CLL?
Funny ...I never thought of
chlorambucil
and cyclophosplomide as human carcinogens, but they are.... I always viewed then as doing good, which they do....
Funny ...I never thought of
chlorambucil
and cyclophosplomide as human carcinogens, but they are.... I always viewed then as doing good, which they do....
Cllcanada
Top Poster CURE Hero
in
CLL Support
11 years ago
Doctors should use different therapies when treating older and younger CLL patients
Key conclusions include: Fludarabine versus
chlorambucil
: Fludarabine improved progression-free survival and overall survival among patients younger than age 70 but
chlorambucil
tended to produce higher overall survival in patients older than 70.
Key conclusions include: Fludarabine versus
chlorambucil
: Fludarabine improved progression-free survival and overall survival among patients younger than age 70 but
chlorambucil
tended to produce higher overall survival in patients older than 70.
Cllcanada
Top Poster CURE Hero
in
CLL Support
12 years ago
I'm new to the site! My story!
My lymph glands swelled considerably and in 2006, I had
chlorambucil
which was effective. In 2009, my lymph glands swelled again and I was told I would need to have FCR treatment (Fludaribine, cyclophosamide and Rituximab).
My lymph glands swelled considerably and in 2006, I had
chlorambucil
which was effective. In 2009, my lymph glands swelled again and I was told I would need to have FCR treatment (Fludaribine, cyclophosamide and Rituximab).
Marisa
in
CLL Support
12 years ago
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