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Chlorambucil
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Chlorambucil
I had
Chlorambucil
along with Rituximub infusions which put me in remission for 2 years. The only side effects were nausea. They tried me initially on Obinutzumib but I had anaphylaxis and it was terminated. Hope this helps. Jan x
I had
Chlorambucil
along with Rituximub infusions which put me in remission for 2 years. The only side effects were nausea. They tried me initially on Obinutzumib but I had anaphylaxis and it was terminated. Hope this helps. Jan x
JanChas
in
CLL Support
3 years ago
NICE Approves Acalabrutinib (Calquence) for specified groups of CLL patients in England
Patients for whom
chlorambucil
would've been an option at that time would have been the less fit patients who could not have tolerated FCR or BR.
Patients for whom
chlorambucil
would've been an option at that time would have been the less fit patients who could not have tolerated FCR or BR.
Jm954
in
Leukaemia CARE
3 years ago
NICE Approves Acalabrutinib (Calquence) for specified groups of CLL patients in England
Patients for whom
chlorambucil
would've been an option at that time would have been the less fit patients who could not have tolerated FCR or BR.
Patients for whom
chlorambucil
would've been an option at that time would have been the less fit patients who could not have tolerated FCR or BR.
Jm954
Administrator
in
CLL Support
3 years ago
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NICE Recommends Acalabrutinib for treating CLL for certain groups
If FCR or BR is unsuitable,
chlorambucil
plus obinutuzumab is offered instead. Clinical trial evidence in this group shows that CLL takes longer to progress when treated with acalabrutinib compared with
chlorambucil
plus obinutuzumab. However, the overall survival benefit is uncertain.
If FCR or BR is unsuitable,
chlorambucil
plus obinutuzumab is offered instead. Clinical trial evidence in this group shows that CLL takes longer to progress when treated with acalabrutinib compared with
chlorambucil
plus obinutuzumab. However, the overall survival benefit is uncertain.
Jm954
Administrator
in
CLL Support
3 years ago
How things have changed
Today we have the alternatives of FCR, monoclonal antibodies, -all the ...mab treatments - BTK inhibitors,
Chlorambucil
, Venetoclax and so on and most, if not all of us can look forward to much longer survival times and survival in good health.
Today we have the alternatives of FCR, monoclonal antibodies, -all the ...mab treatments - BTK inhibitors,
Chlorambucil
, Venetoclax and so on and most, if not all of us can look forward to much longer survival times and survival in good health.
SERVrider
in
CLL Support
3 years ago
85 year old not coping with nor responding to treatment
He has had 3 treatments of Obinutuzimab and
Chlorambucil
, the first one made him so ill he was rushed to ICU. Now he seems to have hemalosis, as his RBC is very low at 70 and will not increase even after 8 blood transfusions this week! We are so worried. Anyone in a similar position?
He has had 3 treatments of Obinutuzimab and
Chlorambucil
, the first one made him so ill he was rushed to ICU. Now he seems to have hemalosis, as his RBC is very low at 70 and will not increase even after 8 blood transfusions this week! We are so worried. Anyone in a similar position?
TKB2020
in
CLL Support
3 years ago
Desperate for answers please...
Scan ruled out kidney stones, doctors unsure of the cause. 2 doses of Obinutuzimab and
Chlorambucil
plus 2 more treatments have not done a thing for his CLL. Awaiting results of bone marrow biopsy. He has had 10 transfusions in 2 weeks, just keeping him out of the danger zone.
Scan ruled out kidney stones, doctors unsure of the cause. 2 doses of Obinutuzimab and
Chlorambucil
plus 2 more treatments have not done a thing for his CLL. Awaiting results of bone marrow biopsy. He has had 10 transfusions in 2 weeks, just keeping him out of the danger zone.
TKB2020
in
CLL Support
3 years ago
WBC over 200.000
He told me he meant
Chlorambucil
, not Cyclophosphamide. He wants to start
Chlorambucil
+ Rituximab. Sorry for mistake. I confused :(
He told me he meant
Chlorambucil
, not Cyclophosphamide. He wants to start
Chlorambucil
+ Rituximab. Sorry for mistake. I confused :(
cllmeonmycellphone
in
CLL Support
4 years ago
SF3B1 Mutations
If and when these patients need treatment they should have a targeted therapy or look for a clinical trial of novel agents, rather than have chemo-immunotherapy such as FCR, BR or
Chlorambucil
. https://ashpublications.org/blood/article/121/23/4627/31480/SF3B1-mutations-in-chronic-lymphocytic-leukemia
If and when these patients need treatment they should have a targeted therapy or look for a clinical trial of novel agents, rather than have chemo-immunotherapy such as FCR, BR or
Chlorambucil
. https://ashpublications.org/blood/article/121/23/4627/31480/SF3B1-mutations-in-chronic-lymphocytic-leukemia
Jm954
Administrator
in
CLL Support
4 years ago
Monitoring the basics
This was Obinutuzumab +
Chlorambucil
for 6 months. Unfortunately, the treatment was aborted after 5 months due to the Covid-19 pandemic.
This was Obinutuzumab +
Chlorambucil
for 6 months. Unfortunately, the treatment was aborted after 5 months due to the Covid-19 pandemic.
Ageon
in
CLL Support
4 years ago
In what situations would Chlorambucil still be used?
I've just heard of a patient is the U S a a major hospital, with good insurance being started on
chlorambucil
to treat CLL. I know he has kidney issues from the CLL. I'm just wondering why they wouldn't use one of the newer drugs? john
I've just heard of a patient is the U S a a major hospital, with good insurance being started on
chlorambucil
to treat CLL. I know he has kidney issues from the CLL. I'm just wondering why they wouldn't use one of the newer drugs? john
johnl
in
CLL Support
4 years ago
CLL/SLL Roundtable: Updates on Patient Management (including low dose radiation treatment for early stage SLL)
In that study, venetoclax plus obinutuzumab led to significant improvement in PFS and higher MRD negativity vs
chlorambucil
plus obinutuzumab.
In that study, venetoclax plus obinutuzumab led to significant improvement in PFS and higher MRD negativity vs
chlorambucil
plus obinutuzumab.
AussieNeil
Administrator
in
CLL Support
4 years ago
Unmutated patients on venetoclax?
In it, she refers to the trial where patients on venetoclax + obinutuzumab had much better results than those on
chlorambucil
+ obinutuzumab. However, she also noted that mutated patients on both treatments fared better than unmutated patients.
In it, she refers to the trial where patients on venetoclax + obinutuzumab had much better results than those on
chlorambucil
+ obinutuzumab. However, she also noted that mutated patients on both treatments fared better than unmutated patients.
HikerBiker
in
CLL Support
4 years ago
Venetoclax plus obinutuzumab - the first chemotherapy-free, fixed-duration first line CLL treatment approved by Health Canada
plus one year of treatment with VENCLEXTA had clinically meaningful and statistically significant progression-free survival (PFS) and higher rates of undetectable minimal residual disease compared to patients receiving a standard of care chemoimmunotherapy regimen of obinutuzumab and
chlorambucil
plus one year of treatment with VENCLEXTA had clinically meaningful and statistically significant progression-free survival (PFS) and higher rates of undetectable minimal residual disease compared to patients receiving a standard of care chemoimmunotherapy regimen of obinutuzumab and
chlorambucil
AussieNeil
Administrator
in
CLL Support
4 years ago
Leukaemia Care Webinar 8th April - a bit more information
That might be
chlorambucil
or, as AdrianUK mentioned yesterday, there is a patient access scheme for Acalabrutinib which is a good alternative for many patients.
That might be
chlorambucil
or, as AdrianUK mentioned yesterday, there is a patient access scheme for Acalabrutinib which is a good alternative for many patients.
Jm954
Administrator
in
CLL Support
4 years ago
Analysing and Resequencing Gene Panels from the UK CLL4 trial (1999-2004) is helping patients today.
The CLL4 study compared conventional
chlorambucil
therapy versus fludarabine - alone or in combination with cyclophosphamide - note there was no Rituximab in those days. End points were: survival, response to therapy, duration of response, toxicity and quality of life.
The CLL4 study compared conventional
chlorambucil
therapy versus fludarabine - alone or in combination with cyclophosphamide - note there was no Rituximab in those days. End points were: survival, response to therapy, duration of response, toxicity and quality of life.
Jm954
Administrator
in
CLL Support
4 years ago
Adding Venetoclax to Obinutuzumab Prolongs Progression-Free Survival in Previously Untreated CLL
[i]Dated 1st September 2019[/i] In a phase III trial of patients with previously untreated CLL a
nd co-existing comorbidities, a fixed-duration regimen
of obinutuzumab plus venetoclax reduced the risk of disease progression and death by 65%, compared with obinutuzumab plus
chlorambucil
.
[i]Dated 1st September 2019[/i] In a phase III trial of patients with previously untreated CLL a
nd co-existing comorbidities, a fixed-duration regimen
of obinutuzumab plus venetoclax reduced the risk of disease progression and death by 65%, compared with obinutuzumab plus
chlorambucil
.
Jm954
Administrator
in
CLL Support
5 years ago
Time for a change!
I have just started on Obinutuzomab and will add
chlorambucil
when I return from a holiday next month.
I have just started on Obinutuzomab and will add
chlorambucil
when I return from a holiday next month.
Paul_Cabban
Champion
in
Leukaemia CARE
5 years ago
Mode of Progression After Frontline Treatment Predicts Clinical Outcomes in Patients With CLL
[/i] The clinical trials included in the evaluation were FCR vs FC, FCR vs BR and obinutuzumab in combination with
chlorambucil
as compared to rituximab plus
chlorambucil
or
chlorambucil
.
[/i] The clinical trials included in the evaluation were FCR vs FC, FCR vs BR and obinutuzumab in combination with
chlorambucil
as compared to rituximab plus
chlorambucil
or
chlorambucil
.
AussieNeil
Administrator
in
CLL Support
5 years ago
Kenab
I'm on
chlorambucil
chemo 9months now but prognosis is not good,spleen is grossly enlarging hence abdominal distention and fullness, what can l do?
I'm on
chlorambucil
chemo 9months now but prognosis is not good,spleen is grossly enlarging hence abdominal distention and fullness, what can l do?
KNAB
in
CLL Support
5 years ago
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