GGT 260 and elevated LFTs

[RedTigeress]

I have had intermittent raised LFTs off and in for the past 15 years. I have hypercholesterolaemia.Recent blood test had my GGT at 260 and LFTs over 100. My GP doesn't seem to think it's an urgent matter. I would welcome your thoughts.

[LolaWT]

Hi, I recently had a blood test I requested as I was taking alot of ibuprofen and naproxen for severe hip arthritis and sciatica and wanted to check my kidneys were alright, they were but my ggt was 212 and both ast and alt were over a 100. After looking online I was completely freaked out as I read a GGT over 200 was liver damage. I have since found out I have a mild fatty liver (I am mildly in the overweight BMI category) and gallstones and the gallstones can raise the ggt. 6 weeks later after a restricted diet, no alcohol (I barely drink anyway) my ggt has gone down to 89 (it was 28 4 years ago and I drink less now and am thinner). I was concerned about the ggt still being high and 2 doctors said it was fine they regularly saw people with it at 800 or in the 1000's and not necessarily cirrhosis. Please don't stress yourself out too much about it, if they don't think it's a concern just ask them what they think you should do to bring it down.

[Smegmer]

Although your GP does not consider it urgent, persistent LFT elevation over 100 and GGT at 260 is significant and warrants further evaluation. You may consider:

Repeat LFTs in 4–6 weeks to check for trends.

Ultrasound of the liver to assess for fatty liver, cirrhosis, or bile duct abnormalities.

FibroScan or liver elastography to assess liver stiffness (early fibrosis or cirrhosis).

Full liver panel:

Bilirubin, ALP, AST, ALT, GGT

Albumin & INR (for synthetic liver function)

Viral hepatitis screen (HBV, HCV)

Autoimmune liver markers (ANA, SMA, IgG)

Iron panel (Ferritin, Transferrin Saturation)

Lipid profile & glucose/HbA1c (if metabolic disease is suspected)