AST/ALT ratio

[ToughToes]

Hi folks,

I read online that an AST/ALT ratio greater than 1.2 can mean advanced liver disease. On August 9 I had a liver enzyme blood test done and all the results were well within normal; however, when I used an AST/ALT calculator tool online, it said I had a ratio score of 1.4 and that this could mean serious liver fibrosis or cirrhosis. I've attached a screenshot if the results and would appreciate any input. Oh, I used another online calculator tool for Fib-4 (using AST, ALT & platelet count) and it showed a score if 0.42, which was very minimal seriousness. Which test is more reliable as an indicator of severity?

[MINTVCX]

Fib-4 is better (validated) than simple AST/ALT ratio (not the best within normal AST and ALT value). The best check with your own doctor.

[ToughToes in reply to MINTVCX]

Ok. Thanks.

[Motik]

My AST/ALT ratio is 1.7.. it when like this after my hcv treatment.. but my liver seems ok my fibroscan is low.. so no worries

[ToughToes in reply to Motik]

So, you haven't been diagnosed with cirrhosis? What is HCV treatment?

[Motik in reply to ToughToes]

No, I havent. HCV is Hepatitis C. My ratio was normal before the treatment, but for some reason after it my ratio become 1.7. After that i had ultrasound, fibroscan, gastroscopy.. all seemed fine, no abnormalities..

[ToughToes in reply to Motik]

I see.

[ToughToes in reply to Motik]

Also, are your LFT's (Iiver enzymes) all within normal limits?

[Motik in reply to ToughToes]

Yes, my liver enzymes and my other bloods are in range.

[ToughToes in reply to Motik]

So, it's only the ratio that's a bit off?

[Motik in reply to ToughToes]

Yes, only the ratio. Why are you panicking so much, only because of the ratio?

[ToughToes in reply to Motik]

No, because I had a gastroscopy on July 12 and the GI noted portal gastropathy, which is usually caused by cirrhosis. My GP senr me for an ultrasound and LFT'S about 2 weeks ago. All normal except for grade 1 mild fatty liver, which was unchanged from two previous scans in 2021 and 2020. I thought those results were good, but then she (my GP) referred me to an internist to inquire about whether he thought I should get a fibroscan.

I saw him this morning snd hoped that when he saw the latest ultrasound and LFT's he'd say no point in doing a fibroscan. However, he sent me for a complete blood count and a repeat of my LFT's, plus a fibroscan.

[Ruggerhead]

tough toes the ratio has no relevance when your levels are normal. I have had those ratios since forever. It only applies when ratios are seriously elevated. Your ast and alt levels fluctuate all the time, they are meant to.

[devkermeg]

My liver doctor said the ratio only is used when numbers are way out of range. If ALT and AST are normal no worries. Play with the calculator and you’ll see how hard it is to have a perfect ratio.

[ToughToes]

Thanks. Good advice!