Compensated Cirrhosis - Sudden Extreme Increase in Liver Stiffness - Under Treatment, Blood Tests Normalized

[ZeroInfiniti]

During annual medical tests in Feb 2024:

- Saw elevated Liver Enzymes, Hi bilirubinFibroscan (ordered by Dr) Stage 2 Fatty Liver, LSM 12.59, Early eosphageal varices, normal platelets (low end of normal)

- Compensated Child-A Cirrhosis

- Diabetic, high Cholesterol, hi triglycerides Hypertension: All numbers were high

Taking Medicines for all.

Advised exercise, weight loss, healthy diet (high protein). Saroglitazar (PPAR agonist), Vitamin E.

After 3 months

- Liver Enzymes normal

- Bilirubin almost normal

- Hba1c, Blood pressure, Cholesterol normal , Still high triglycerides

Update:

I got a fibroscan today after being on the medication and healthy lifestyle regimen and hoping to see improvement.

To my utter horror and shock, the liver stiffness is 74 kpa with the Fibroscan. It was 12.59kpa 3 months back with another non Fibroscan Transient Elastography.

The technician tested 2-3 times to confirm the numbers

I am at loss as to what happened. My metabolic numbers have returned to normal/acceptable with my recent tests. How could my liver stiffness go off the chart in 3 months while under treatment?

My view of the possibilities:

- Rapid worsening of the condition

- Some other inflammation of the liver

- Operator measurement problem

I will meet my Doctor soon. Any clues/pointers will be much appreciated

[SkinNBones]

maybe i misunderstood but did you say the stiffness numbers came from two seperate tests? If so, maybe they cannot be compared quantitatively.? Have heard elastograph is better for assessing stiffness. I havent had either yet tho need.

[ZeroInfiniti in reply to SkinNBones]

Yes, they came from two different tests.Both are Elastography based. - one Fibroscan and the other Another Company's Transient Wave Elastography Equipment. They use the same scale and gradation.

[cammeag]

Sorry to hear of your kpa results accelerating so quickly 😢. IF the readings are correct then something like medication has accelerated liver inflammation. You need to raise your concerns asap, better with your gastro team. I would also push for another fibroscan just to be certain. You could do a check on current meds as well and likelihood of liver inflammation as side effects. Really hope you get this sorted. All the best.