Fibrosure test

[Realy]

anyone have this test done? And it accuracy ?

[Fibro2021]

FibroSURE™ is a serum biomarker test that is designed to assess liver fibrosis in patients with chronic viral hepatitis B or C, alcoholic liver disease, and metabolic steatohepatitis. the negative predictive value of clinically significant fibrosis was 91% and the positive predictive value for presence of significant fibrosis was 61%-76%. FibroSURE is a combination of five biochemical assays: alpha2-macroglobulin, haptoglobulin, apolipoprotein A1, gamma glutamyl transpeptidase (GGT) and total bilirubin. An additional component – alanine aminotransferase (ALT) – is infrequently used to test for necroinflammatory lesions. This addition is known as ActiTest. The results of these assays are taken into account along with a patient’s age, gender, height and weight for the final FibroSURE score and/or ActiTest. This test is not correct for patients with established Gilbert's syndrome, since one of the calculated indicators is total bilirubin. In patients with Gilbert's syndrome, this test may be falsely high. Perhaps someone who has already done this test will write their opinion about it here.

[Realy in reply to Fibro2021]

is it used with Nafld as well?

[Fibro2021 in reply to Realy]

If NAFLD is suspected, another test is used, namely the NASH FibroSure test. NASH FibroSure® is recommended for patients with suspected nonalcoholic fatty liver disease. This test is a noninvasive assessment of liver status in patients with nonalcoholic fatty liver disease (NAFLD). It is not recommended for patient with other liver diseases. It is also not recommended in patients with Gilbert disease, acute hemolysis, acute hepatitis, acute inflammation of the liver, autoimmune hepatitis, extrahepatic cholestasis, transplant patients, and/or renal insufficiency patients. Any of these clinical situations may lead to inaccurate quantitative predictions of fibrosis. It uses ten biochemical indicators for calculation. a2-macroglobulin, haptoglobin, apolipoprotein A1, bilirubin, y-glutamyl transpeptidase (GGT), alanine aminotransferase (ALT),aspartate aminotransferase (AST), total cholesterol, triglycerides, and fasting glucose​. Quantitative results of 10 biochemicals in combination with age, gender, height, and weight are analyzed using a computational algorithm. Please, note that the name FibroSure is used in the USA for FibroTest.