Hi all
I've been told I have HA result of 90 (upper range of 75 is normal). I'm confused by googling (I know always a bad idea) as seems like HA levels that signify significant and severe fibrosis are relative to the type of liver disease ie so 50 might be a high result for NASH. For other types of LD it's very high HA levels that signify severe fibrosis
I am having a biopsy too but just confused. My other blood tests are ok (Fib 4 of 1.03)
Anyone understand HA well?
Not sure what you are asking here? Hyaluronic acid is something that is used in skincare products and is associated with attracting moisture into the skin, definitely not something associated with fibrosis. Googling is a bad idea whatever you have since there are many articles that seem to suggest that they have researched the facts, but they are not based in fact at all. Best to stick to the articles posted by the British LIver Trust or instead talk to someone on the Helpline who could clarify things for you. All the best 
It is a marker test, one of many, to help indicate the degree of fibrosis. Yes it is found all over the body. High values in the liver are helpful in determining the amount of fibrotic tissue
Looking into this, it seems as if it is something that is most likely to have come from the ELF test. Even if I understood it (I've never had one), I would not be able to comment on the numbers and nor would anyone else since we are not allowed to interpet results. In fact the BLT asks people not to post results for interpretation since none of us are medically qualified to do so. Determining the level of fibrosis is not an exact science I'm afraid and requires information from various sources to put together a clear picture. This is probably why they have requested a biopsy to give them a clearer picture.
Sorry I can't give you an answer, but maybe your GP could help you?
ncbi.nlm.nih.gov/pmc/articl...
this is an excerpt from the study above
In patients with NASH but without fibrosis HA levels varied within the normal range of healthy population. The best cut-off value was at 148.8 ng/mL for the identification of patients with NAFLD and fibrosis (sensitivity was 95.7%, specificity 96.3%, PPV 95.7%, NPV 96.3% and accuracy of 96%
I have looked at two different papers (one from 2011 and the one cited below from 2016) and they both seem to say the same thng. The HA is useful for determining levels of fibrosis if it is F2/3/4. However, since I am not an expert, I think I'll leave it there. I have at least learned that HA is a biochemical marker for fibrosis, so thanks for that
Nash , liver pain and also spleen pain
Idiopathic NASH?
Ongoing treatment for NASH
just diagnosed with NASH
Lost trust in elastography
