I gather about 50% of PBC ers suffer severe fatigue. I was one. I received a transplant 12 months ago, I still experience fatigue, nothing like as extreme as pre transplant, but I need 2 - 3 hours sleep each afternoon or I am so sleepy I can not function. I had hoped that exercising might help, and that the longer from transplant I might get stronger etc. well exercise knocks me out I ramped gently to 5 minutes jogging at 8 Km / hr. and was so exhausted I felt it counter productive....do other transplant patients experience this tiredness or similar?