Risedronate Sodium v Denosumab (Prolia)

[Calamintha]

I have read that if you stop taking prolia, you can get rebound effects.

Is this also true with Risedronate ? I am still in a deliberating which to take (if any)

Thanks

[Ronnie101]

I'm in the same situation. My understanding is that you can stop risondrate at any time without Ill effects.

[Calamintha in reply to Ronnie101]

Thats why I've dedided to try it. I was waiting to get a grip on the acid reflux after I came off omeprozole.

[CloudyD]

Hi. They're both quite different treatments. Here's a link to the ROS list of osteoporosis treatments and what they involve:

theros.org.uk/information-a...

I'm not aware of any "rebound" after Risedronate, I've only heard of it from Prolia (after which people are often put on bisphosphonates to counteract the loss of protection). But your treatment options prescribed by your doctor will depend on your personal medical history and need. The ROS states Denosumab is not usually a first line treatment but given when you've tried others and they've not been suitable - but maybe your scores or medical history are such that it's a better option for you.

[Calamintha in reply to CloudyD]

Thanks; My first treatment was AAcid which I had an appauling reaction to

[CloudyD in reply to Calamintha]

Personally, and I stress that it's a personal choice, I would go for the risedronate (which I'm on and I don't experience side effects so far on my existing gastric and oesophogus problems) over the Prolia/Denosumab. But looking at some reports it seems its results are slower or lower than other treatments so I guess that depends on how bad your situation is. My spine is around -4.75 (from memory which may be wrong), which I take to be a bad score but if you're lower than that you may need something that works quicker/harder for the short term.

[Raleigh59 in reply to CloudyD]

did you try fosamax or AAcid? The reason I ask is I’ve tried AAcid and ibandronate with bad side effects. And I’ve heard risendronate has the least side effects which I am trying next but it will cost me $56 per month. And my spine is -4.7 which yes is a bad score.

[CloudyD in reply to Raleigh59]

I was put on risedronate straight away so I've no idea if I would have had problems with the other types of bisphosphonates. OP Calamintha was on AA tho.

[Raleigh59]

my dr said the only medicine with rebound effects is Prolia.

[Lucy1578]

I was on AA for 6 months…..absolutely awful, now on Risedronate for the past 18 months and feel fine . Due a scan towards the end of the year, fingers crossed for the results.

[Mavary]

Hi! I took Terraparatide for two years. I had to change then to another drug because you can only take Terraparatide for two years. I was then put on Denosumab but it was for some reason delayed for a couple of weeks. It resulted in me having four more spinal fractures. So whether this happens with stopping any of the bone meds I don’t know. My bone dexa was very bad so if yours is not too bad you may get away with it. You can only ask advice. My bone dexa scan was -5.5 to start with. After the Terraparatide it was -4.6 so still not good. I’ve been told I will be on Denosumab for life. And I mustn’t delay my infusions.

So my advice to you is to speak to the Osteoporosis Society.

[Mavary in reply to Mavary]

just to add. I took one AA and was really sick luckily I was in hospital after my T 12 went and they could see what I was like . I never had anything then until I got home after twelve days. I then had a Nurse come to show me just the once how to do Terraparatide injections.;I never thought I would ever be able to do that but after a week or two I was fine.

I’ve never had any ill effects from either Terraparatide or Denosumab. I’ve got no worries about coming off them because as I said they are for life. I’m quite happy with what I’m on. I know there’s a lot of controversy about it but it suits me. Maybe if I had known all the ins and outs of all the drugs I probably would have been more hesitant about taking them. I just trusted the medical profession. I knew nothing about Osteoporrosis when my bones first went.

[Rocknlily]

I was on Fosomax. Had to get off of it due to side effects. Interestingly enough, my doctor offered me the Reclast first. After reading about it, I was hesitant. Then she said then do the Prolia, it’s even safer with less effects on kidney (concern of mine as a Transplant patient). I’m deliberating. Want to deal with some other issues first. Wish there were other safer classes of drugs.