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Risedronate

Risedronate (risedronate sodium) is a type of medicine called a bisphosphonate. It helps your bones stay as strong as possible.

It can help if you have or are at risk of getting a health condition called osteoporosis. This is where your bones get weaker and more likely to break.

Osteoporosis can happen for many reasons, but you're more likely to get it if you're a woman who has been through the menopause or if you take steroids, such as prednisolone, for a long time. Some types of cancer treatment can also increase your risk of getting osteoporosis.

Risedronate can also help people who have Paget's disease of bone. This weakens your bones and they can become deformed. Risedronate helps to reduce these bone changes, reduce pain and make your bones stronger and less likely to break.

Risedronate comes as tablets and is only available on prescription.

Who can take risedronate

Most adults aged 18 and over can take risedronate.

It's occasionally prescribed for children with osteoporosis.

Risedronate is not suitable for some people. To make sure it's safe for you, tell your doctor if you:

  • have ever had an allergic reaction to risedronate or any other medicine
  • have digestive problems, problems swallowing or any problems with your food pipe (oesophagus)
  • cannot sit up or stand for at least 30 minutes
  • have low calcium levels in your blood – taking risedronate could make them even lower
  • have kidney problems
  • have cancer, or are having chemotherapy or radiotherapy
  • have problems with your teeth, or are waiting for dental treatment such as having a tooth out
  • smoke or used to smoke – this may increase your risk of dental problems
  • are pregnant or breastfeeding, or trying to get pregnant

Dosage and strength

Risedronate tablets come in strengths of 5mg, 30mg and 35mg.

For Paget's disease of bone, the usual dose for adults is 30mg, taken once a day.

For osteoporosis, the usual dose for most adults is 35mg taken once a week. You may prefer to take 5mg, once a day.

Take your medicine first thing in the morning, when you get up. Take it on an empty stomach, at least 30 minutes before you have anything to eat or drink (other than plain water) and before you take any other medicines or supplements.

It's important to take risedronate while you're sitting up or standing, so that it does not irritate or damage your food pipe (oesophagus). Stay upright for 30 minutes after taking your medicine.

Risedronate works best when your stomach is empty, so your body can absorb it properly.

If you cannot take it first thing in the morning, you can take it later in the day, but in this case do not eat or drink anything (other than plain water) or take any other medicines for 2 hours before and after taking your tablet.

Swallow the tablet whole with a large glass of plain tap water (at least 120ml). Do not chew, break, crush or suck the tablet. Do not take it with mineral water.

It's important to follow the instructions for this medicine very carefully. If you do not, it may not work, or it could irritate and damage your food pipe as you swallow it.

How long to take it for

How long you'll need to take risedronate depends on why your doctor has prescribed it.

For Paget's disease of bone, you'll usually take it for 2 months. You may need to start taking it again if your symptoms come back.

For osteoporosis, you'll usually take risedronate for a long time.

If you're having long-term treatment with steroids, you'll usually take risedronate until your steroid treatment stops, and maybe for longer.

If you have osteoporosis, your doctor will usually assess your risk of broken bones after 5 years. This may include tests to check the strength (density) of your bones.

Depending on the results, you'll either keep taking risedronate, take a break from it or stop taking it completely.

If you forget to take it

If you miss a dose, what you do next depends on how often you're supposed to take risedronate. If you usually take it:

  • once a day (5mg or 30mg) – take it later in the day, but do not eat or drink anything (other than plain water) or take any other medicines or supplements by mouth for 2 hours before and 2 hours after taking the tablet. If this is not possible, then just skip the missed dose and take your next dose on the following day, in the morning
  • once a week (35mg) – wait until the next day and then take your medicine first thing in the morning. After this, go back to taking your weekly dose on your usual day

Never take 2 doses to make up for a forgotten one.

If you take risedronate once a week, some packaging has a space to mark the day of the week and the dates you take your tablets. This can help you remember to take your medicine on the right day.

If you often forget doses, it may help to set an alarm to remind you. You could also ask your pharmacist for advice on other ways to help you remember to take your medicine.

If you take too much

If you take an extra dose of:

  • your 5mg daily or 35mg weekly tablet – it's unlikely to harm you. Drink a full glass of milk immediately if you can, and stay upright for at least 30 minutes
  • your 30mg daily tablet – drink a full glass of milk immediately if you can, and stay upright for at least 30 minutes

If your child takes an extra dose, get them to drink a full glass of milk immediately if possible. Contact their doctor or contact 111 straight away. Keep your child sitting up or standing for at least 30 minutes.

Do not make yourself or your child sick (vomit), as this may irritate the food pipe.

  • you take more than 1 extra dose of risedronate

Go to 111.nhs.uk or call 111

If you need to go to A&E, do not drive yourself. Get someone else to drive you or call for an ambulance.

Take the risedronate packet, or the leaflet inside it, plus any remaining medicine with you.

Common side effects

These common side effects of risedronate happen in more than 1 in 100 people. There are things you can do to help cope with them:

Speak to a doctor or pharmacist if the advice on how to cope does not help and a side effect is still bothering you or does not go away.

Some people may have serious side effects when taking risedronate.

Tell a doctor or contact 111 straight away if you have:

  • heartburn (or heartburn that gets worse), or problems or pain when swallowing – these may be signs of ulcers in your food pipe. If this happens, stop taking risedronate and speak to a doctor
  • a loose tooth, mouth sores, or swelling or pain in your mouth or jaw – contact your dentist as well as your doctor, as this could be a sign of damage to your jawbone
  • pain, weakness or discomfort in your thigh, hip or groin – this happens rarely but may be an early sign of a broken thigh bone
  • severe pain in the joints, muscles or bones
  • ear pain, discharge from your ear or an ear infection – these can be signs of damage to the bones in your inner ear
  • black or red poo – these can be signs of an ulcer or bleeding from your gut
  • blurred vision, light sensitivity, or painful or red eyes – these can be signs of swelling of the eye
  • muscle cramps or spasms, a tingling sensation in your fingers or around your mouth – these can be symptoms of low calcium levels in your blood

Go to 111.nhs.uk or call 111.

Serious allergic reaction

In rare cases, risedronate may cause a serious allergic reaction (anaphylaxis).

For a very small number of people, taking risedronate for more than 2 years can increase their chances of getting a rare type of bone damage in their inner ear and certain types of breaks to their thigh bones.

If risedronate is working for you long term, your doctor will look at the benefits and risks of your treatment after 5 years. They may do some tests to check the strength (density) of your bones. Then they'll advise you if you should keep taking it.

The benefits of taking risedronate generally outweigh the risks. If you're concerned or have any questions, talk to your doctor or pharmacist.

Other side effects

These are not all the side effects of risedronate. For a full list, see the leaflet inside your medicine packet.

Risedronate and pregnancy

Risedronate is not generally recommended during pregnancy because there is little information on its safety.

If you become pregnant while taking risedronate, contact your doctor or hospital specialist for advice about whether to keep taking it or not.

If your doctor says your baby is healthy, you can take risedronate while you're breastfeeding.

It is likely that only tiny amounts will get into your breast milk which would not be expected to cause any problems in your baby.

Although it's generally OK to take this medicine while breastfeeding, it may not be suitable in a very few cases. Check with your doctor about what's best for you and your baby.

If your baby is not feeding as well as usual, is being sick or is constipated or you have any other concerns about your baby, talk to your doctor, pharmacist, health visitor or midwife.

Risedronate and fertility

There's no good evidence to suggest that taking risedronate reduces fertility in either men or women.

If you're trying to get pregnant and are taking risedronate, speak to your doctor or hospital specialist. This is because they may consider taking you off the medicine while you're trying to get pregnant.

Cautions with other medicines

When taking risedronate, it's important to not take any other medicines at the same time. This is because other medicines can affect how well your body absorbs risedronate and may stop it working properly.

If you take risedronate first thing in the morning, when you get up, wait for at least 30 minutes before taking your other medicines.

If you take risedronate between meals or in the evening, wait at least 2 hours before taking your other medicines.

Tell your doctor if you're taking:

  • antacids to relieve indigestion or heartburn such as Maalox, Mucogel or Milk of Magnesia
  • laxatives containing magnesium such as Milk of Magnesia
  • cancer medicines such as bevacizumab or thalidomide, or if you're having chemotherapy or taking steroids such as prednisolone or dexamethasone – these may increase the risk of damage to your jawbone
  • non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, which can increase the risk of irritating your food pipe, stomach or gut – taking low-dose aspirin is OK
  • antibiotics such as gentamicin, amikacin, streptomycin or tobramycin – these can lower the calcium in your blood
  • deferasirox, a medicine used to remove excess iron from the body – this may increase the risk of bleeding from your gut
  • parathyroid hormone, a medicine used to treat hypoparathyroidism

Tell your doctor if you're taking supplements or multivitamins containing calcium, iron, magnesium or zinc. These supplements can reduce the amount of risedronate absorbed from your stomach if you take them at the same time.

If you take your risedronate in the morning, consider taking your calcium, iron, magnesium or zinc supplement in the evening.

There's not enough information to say that other complementary medicines, herbal remedies and supplements are safe to take with risedronate. They're not tested in the same way as pharmacy and prescription medicines. They're generally not tested for the affect they have on other medicines.

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117 public posts

Risedronate

, and the second one suggesting I also start taking Risedronate to prevent development of osteoporosis. I am 73. My age was not cited as the main reason but that I have been on high doses of steroids over that last few years . (I know many on here are far higher than me).
, and the second one suggesting I also start taking Risedronate to prevent development of osteoporosis. I am 73. My age was not cited as the main reason but that I have been on high doses of steroids over that last few years . (I know many on here are far higher than me).
Wheezycat profile image
Wheezycat
in Asthma Community Forum
2 months ago

Predisone & Risedronate DR - take at same time?

They told me that I should be taking the Risedronate on an empty stomach and that I should take the two medications ~2 hrs apart. I told them that there was a sticker on the package stating to "Take with food".
They told me that I should be taking the Risedronate on an empty stomach and that I should take the two medications ~2 hrs apart. I told them that there was a sticker on the package stating to "Take with food".
LucilleG profile image
LucilleG
in PMRGCAuk
3 months ago

Alendronic Acid versus Risedronate

Then spoke to yet another GP who said that I could take Risedronate instead but after looking at the possible side effects I stalled with this as well.
Then spoke to yet another GP who said that I could take Risedronate instead but after looking at the possible side effects I stalled with this as well.
Bayleaf1 profile image
Bayleaf1
in PMRGCAuk
2 months ago
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10 year risk of fracture

Risedronate was a disaster. The chart given after dexa scan never explained to me. one thing I keep noticing many have a 10 year risk. I am 74. Had compression fx of spine 10-21 Family history of osteoporosis. Take tamoxifen. Never told I had osteoporosis.
Risedronate was a disaster. The chart given after dexa scan never explained to me. one thing I keep noticing many have a 10 year risk. I am 74. Had compression fx of spine 10-21 Family history of osteoporosis. Take tamoxifen. Never told I had osteoporosis.
Crawldad profile image
Crawldad
in American Bone Health: Osteoporosis
2 months ago

C-Telopeptide serum levels

Mine started at 588 in August of 2019, went on Risedronate 1x week (35mg) and level was down to 178 by October, 2021. Went off Risedronate December, 2021 and now at 375. My doc wants it below 350. I'm 62, all other labs are in great shape, I eat well, get lots of weight bearing exercise.
Mine started at 588 in August of 2019, went on Risedronate 1x week (35mg) and level was down to 178 by October, 2021. Went off Risedronate December, 2021 and now at 375. My doc wants it below 350. I'm 62, all other labs are in great shape, I eat well, get lots of weight bearing exercise.
Hiker11 profile image
Hiker11
in Bone Health
5 months ago

so sick from osteoporosis med. does it get easier?

on week three of taking risedronate delayed release. First two felt sick entire day take 35 mg once a week. this week which is week 3 feel sick day of and still Feel sick. Is there any hope of this getting better? I don’t think I can handle being sick every week.
on week three of taking risedronate delayed release. First two felt sick entire day take 35 mg once a week. this week which is week 3 feel sick day of and still Feel sick. Is there any hope of this getting better? I don’t think I can handle being sick every week.
Crawldad profile image
Crawldad
in American Bone Health: Osteoporosis
3 months ago

Just had first Zoledronate infusion

In 2021 I had a further DEXA scan, which again showed no improvement but my GP advised me to continue taking Risedronate.
In 2021 I had a further DEXA scan, which again showed no improvement but my GP advised me to continue taking Risedronate.
ScrumpyPig profile image
ScrumpyPig
in Bone Health
6 months ago

Exercise query

I haven't been able to tolerate AA, Risedronate or Zoladronic Acid but luckily my fracture scores are low 1.8% - 7%. I was diagnosed just under 2 years ago and only have Osteoporosis in hip neck -2.5, lower spine and hip are in Osteopenia range. I've had no fractures.
I haven't been able to tolerate AA, Risedronate or Zoladronic Acid but luckily my fracture scores are low 1.8% - 7%. I was diagnosed just under 2 years ago and only have Osteoporosis in hip neck -2.5, lower spine and hip are in Osteopenia range. I've had no fractures.
NewBloom profile image
NewBloom
in Bone Health
29 days ago

Alendronic Acid

Informed it was not available till early Sept by my pharmacy GP prescribed Risedronate Sodium until back in stock which hade been problematic burred vision when taking it, indigestion (which I have never had) mouth sores/ulcer after two doses, not going to continue with it, waiting for GP to get back
Informed it was not available till early Sept by my pharmacy GP prescribed Risedronate Sodium until back in stock which hade been problematic burred vision when taking it, indigestion (which I have never had) mouth sores/ulcer after two doses, not going to continue with it, waiting for GP to get back
Derek1951 profile image
Derek1951
in Bone Health
6 months ago

Osteopenia - should I persuade my GP not to prescribe AA?

Makes total sense to me, hence my question… do I really need to take the recommended  Risedronate 35mg weekly? Thankfully my GP does listen!
Makes total sense to me, hence my question… do I really need to take the recommended  Risedronate 35mg weekly? Thankfully my GP does listen!
katzma profile image
katzma
in PMRGCAuk
3 months ago

Asking GP for a referral

My GP prescribed in advance of my Xray, because it took so long to get the results, Risedronate 35mg, Huxley D3 and The ical 1000mg to strengthen bones etc. I am taking Gabapentin, the Diazepam and Morphine Sulphate 10mg/5ml as required when pain is bad!
My GP prescribed in advance of my Xray, because it took so long to get the results, Risedronate 35mg, Huxley D3 and The ical 1000mg to strengthen bones etc. I am taking Gabapentin, the Diazepam and Morphine Sulphate 10mg/5ml as required when pain is bad!
Songbird6 profile image
Songbird6
in PMRGCAuk
4 months ago

delayed release risedronate already refused once year infusion of reclast.

This feed is very scary. Does anyone that was dx with severe osteoporosis have success with medicines. Going to take first dose tomorrow 35 mg once a week. anyone have success? I feel cornered already had compression fracture of spine. Hips a mess. I believe or want to believe med is best. I am
This feed is very scary. Does anyone that was dx with severe osteoporosis have success with medicines. Going to take first dose tomorrow 35 mg once a week. anyone have success? I feel cornered already had compression fracture of spine. Hips a mess. I believe or want to believe med is best. I am
Crawldad profile image
Crawldad
in American Bone Health: Osteoporosis
4 months ago

fragile spine and multiple fractures

I have reluctantly begun Risedronate treatment. I am terrified of more fractures, kyphosis, disability, neverending pain. I am trying to get the IBD under control so that I dont have more steroid treatment as a first step (easier said than done).
I have reluctantly begun Risedronate treatment. I am terrified of more fractures, kyphosis, disability, neverending pain. I am trying to get the IBD under control so that I dont have more steroid treatment as a first step (easier said than done).
Valerie0106 profile image
Valerie0106
in Bone Health
4 months ago

weighted vest

I was diagnosed with osteoporosis in 2017 and started sodium risedronate around 2018. I took it until about 4 months ago when my Endocrinologist took me off to put me on Prolia, which she assured me had no contraindications. Thank God I researched on my own and am determined to stay off drugs.
I was diagnosed with osteoporosis in 2017 and started sodium risedronate around 2018. I took it until about 4 months ago when my Endocrinologist took me off to put me on Prolia, which she assured me had no contraindications. Thank God I researched on my own and am determined to stay off drugs.
Uncertain2 profile image
Uncertain2
in Bone Health
6 months ago

Alendronate (alendronic acid)

They may offer to prescribe another bisphosphonate, such as risedronate. It's important not to delay starting a treatment, particularly if your doctor feels your risk of breaking a bone is high.
They may offer to prescribe another bisphosphonate, such as risedronate. It's important not to delay starting a treatment, particularly if your doctor feels your risk of breaking a bone is high.
ROSAdmin profile image
ROSAdmin
Partnerin Bone Health
6 months ago

Dexa scan results worse than last scan

The doctor gave me Risedronate tablets which I didn’t take because I was worried about the side-effects and also was convinced I could improve my bone density via a natural route.
The doctor gave me Risedronate tablets which I didn’t take because I was worried about the side-effects and also was convinced I could improve my bone density via a natural route.
stillmovin profile image
stillmovin
in Bone Health
8 months ago

Risedronate and parathyroid serum levels

Hoping someone may have some knowledge of parathyroid serum levels whilst on risedronate. My latest blood results showed high parathyroid serum levels . I only started on risedronate 10 weeks ago and my levels were fine prior to this .
Hoping someone may have some knowledge of parathyroid serum levels whilst on risedronate. My latest blood results showed high parathyroid serum levels . I only started on risedronate 10 weeks ago and my levels were fine prior to this .
Looby60 profile image
Looby60
in PMRGCAuk
12 months ago

Letter from rheumatologist

I said I wasn’t to happy about A A do he advised Risedronate and said to go with slow reduction of prednisone as you have advise. Thanks in advance Janet
I said I wasn’t to happy about A A do he advised Risedronate and said to go with slow reduction of prednisone as you have advise. Thanks in advance Janet
Uglow profile image
Uglow
in PMRGCAuk
1 year ago

bone profile blood test

I dont understand why Ive been put on risedronate when my bone profile blood test results are all in normal parameters.
I dont understand why Ive been put on risedronate when my bone profile blood test results are all in normal parameters.
Hidden profile image
Hidden
in PMRGCAuk
1 year ago

Probiotics

Hi All, In a couple months I'll need to try Risedronate again. After two doses I had to stop and have a break. I estimate restarting January. I'm also on Calcuim 500 mg/800 I vit D3. Does an6know if it's ok to take probiotic drinks/yogurt?
Hi All, In a couple months I'll need to try Risedronate again. After two doses I had to stop and have a break. I estimate restarting January. I'm also on Calcuim 500 mg/800 I vit D3. Does an6know if it's ok to take probiotic drinks/yogurt?
NewBloom profile image
NewBloom
in Bone Health
1 year ago
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