New scanning method for osteoporosis - Bone Health and O...

Bone Health and Osteoporosis UK

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New scanning method for osteoporosis

6 years ago•7 Replies

On BBC Midlands there was a news feature tonight on a new scanning device suitable for measuring bone density without using xrays. It was being tested on cricketers in Worcestershire. It sounds like a great idea as it was fairly portable and reduces exposure to radiation. Perhaps it might mean patients could get tested on a yearly basis?

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Nanaedake

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7 Replies

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LynneH-196 years ago

I didn’t see the report, but it sounds interesting from what you say. Anything to cut radiation exposure should be an improvement.

Fran576 years ago

Sounds promising!

Fran 😊

Heather96 years ago

Definitely one to keep an eye on for future development and roll-out - I'm almost one year in now and have been told that I won't get another scan until the standard 5-year term is up. It would give me some peace of mind to know that an annual scan might be available.

Nanaedake in reply to Heather96 years ago

I agree. An annual scan would be helpful.

Met006 years ago

Even better would be something that measures bone strength rather than bone density, as the two aren't always the same.

elaine24475 years ago

Osteoscan UK Ltd

10 August

Faster and more accurate than DEXA! No being strapped down uncomfortably for ages! Quick, on-screen, easy to understand immediate results! Full diagnosis and help/guidance by bone specialist. All in one 30minute appointment.

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5 years ago

Even better, just had this test done after being on Prolia nightmare for 2 years, now on Forteo for 1.5 years with great sucess.

This test allows rapid analysis of bone turnover, just had mine done and it proved out the efficacy of my current modality.

PINP as a biological response marker during teriparatide treatment for osteoporosis

J. H. Krege, N. E. Lane, J. M. Harris, and P. D. Millercorresponding author

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Abstract

Postmenopausal women with severe osteoporosis may require treatment with the bone anabolic drug teriparatide. While changes in bone mineral density (BMD) are one measure of response, BMD changes often require a minimum of one year to observe measureable changes. Biochemical markers of bone turnover change within 1 to 3 months of initiating osteoporosis therapy. Monitoring with a marker such as procollagen type I N propeptide (PINP), an osteoblast-derived protein, during teriparatide treatment may provide clinically useful information for managing patients with osteoporosis. Clinical trials have shown consistent increases in PINP within 3 months of initiating teriparatide, increases that are significantly greater than placebo and significantly different from baseline. Increases in PINP concentrations during teriparatide treatment correlate well with increases in skeletal activity assessed by radioisotope bone scans and quantitative bone histomorphometry parameters. Individuals treated with teriparatide in clinical trials usually experienced an increase in PINP > 10 mcg/L from baseline, while those given placebo usually did not. In the clinical setting, patients experiencing a significant increase in PINP > 10 mcg/L after initiating teriparatide therapy may receive an earlier confirmation of anabolic effect, while those who do not may be assessed for adherence, proper injection technique, or undetected secondary conditions that might mitigate an anabolic response. PINP monitoring may provide information supplemental to BMD monitoring and be a useful aid in managing patients receiving anabolic osteoporosis treatment in the same way that biochemical markers of bone resorption are useful in monitoring antiresorptive therapy. This review examines PINP as a biological response marker during teriparatide treatment for osteoporosis.

Keywords: Anabolics, Biochemical markers of bone turnover, Osteoporosis, PINP, Teriparatide

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