Edoxaban clocks changing

[Parya]

Hello having a cardioversion in May and have been told anticoagulants very important not to miss doses, does it cause a problem when clocks go forward? Does anyone else change their time to allow for this? I'm also going away to Europe soon and there will be hours going backwards and forwards then. Any advice would be helpful

[Lowerfield_no_more]

If its any help I don't let things like clocks changing or trips to different European time zones concern me when it comes to taking medication. I am also relaxed about when I take my medication, and as long as its about the same time period each day I am happy. However if I was to travel to the other side of the world I might give it more thought and perhaps consult with a pharmacist for guidance. So if you are not re-assured by that, why not talk to a pharmacist to enquire about your own medication regime..

[Parya in reply to Lowerfield_no_more]

Yes popping in to see pharmacist today just wanted to see what others do thanks for replying it's just the clinic nurse put such an emphasis on this and I can't get back to her until I receive a letter to ask questions like this as no contact details yet.

[Petercat1 in reply to Parya]

Hi. I actually hadn't thought about that. I had been told its important to take my Apixaban 12 hours apart and about the same times each day. So I would be interested to know what happens when the clocks change too!

[HamishBoxer in reply to Petercat1]

The enclosed notes do state, twice daily, obviously as near equal apart as possible I would think.

[wattsy1985]

When clocks go forward or backward, it's generally safe to adjust your medication time by one hour on the day of the change. If you're concerned, you can gradually adjust your medication time by 15-30 minutes over a few days leading up to the change

[Taviterry]

We had a similar thread a few days ago: healthunlocked.com/bhf/post....

[Parya in reply to Taviterry]

Thank you just read that missed it!

[Bear910]

I read somewhere that as long as it’s within a two hour window of the 12 hours later then it’s fine. I’ve been to the US West Coast from the U.K. for a few weeks holiday and gradually adjusted on this basis on arrival and when I got home.

[sandandkev]

You take it once a day

[Petercat1 in reply to sandandkev]

I take my Apixaban twice a day

[HamishBoxer in reply to Petercat1]

Me too.

[Eeee13]

I’ve been on Apixaban for last 15 months . It takes 10 minutes to start working and starts to wear off after about 12 hours that’s why I have to take it every 12 hours. It takes about 24 hours when I come off it to feel normal again. It really screws me up and have had to come off it several times and go back on at 2 weeks notice before surgery.

[Blackknight57]

medications are flexible, 1 hour either side isn't going to matter.

[aardvark68]

As several people have said already, one hour won’t matter. But a tip that I found useful when traveling across many different time zones was to either wear two watches (in the old days) to easily stick to U.K. dosing times. These days it’s even easier to use World Clock on your phone and set up alarms when meditation is due.

[Driver11]

Been on them a few years and try to take them in the morning around 8am my time That way I don't miss any

Good luck

[Reggaelover]

Hello Parya,

I took edoxaban during an episode of atrial fibrillation, caused by a leak in my mitral valve in 2022. I stayed on the medication even after my heart rhythm was corrected by cardioversion. I had my valve leak repaired last April and my cardiologist told me I could stop the edoxaban in December. I didn’t have set times to take the medication - I just took it in the morning after breakfast, any time between 7am and 10am. So I wouldn’t worry too much about the clocks changing.

Best wishes 🙂

[Lupaal]

I will adjust my morning one by half an hour then take my evening one at the right(new) time then carry on at usual times. That way it's only one dose taken half an hour wrong ,if that makes sense.

[Sixtychick]

I take Edoxaban. After 12 hours, 50% of Edoxaban is still in your body, so a 1 hour time difference shouldn’t affect it. I often take it an hour early, if I’m going out in the evening, so don’t worry about it.

[L8Again in reply to Sixtychick]

I don’t believe that it is quite that simple. Edoxaban has a half life of 10 to 14 hours but it is deemed to be effective as an anticoagulant for 24 hours. Twelve to 24 hours later the prophylactic effect will fall outside of the acceptable clinical range. This is to do with the Pharmacokinetics and Pharmacodynamics of this particular drug which I confess I do not understand.

NHS advice on missed Edoxaban doses is as follows. ‘ If you’re taking rivaroxaban or edoxaban once a day and you miss one of your doses, you should take it as soon as you remember if it’s still more than 12 hours until your next scheduled dose. If it’s less than 12 hours until your next dose, skip the dose you missed and take the next scheduled dose as normal.’

That said, there is a recent EHRA study which is recommending a slightly different protocol for missed/late doses so best advice may well change in the future.

[Mentdent]

I’ve been taking stuff for 15 years and travelled a lot as far as New Zealand etc. I’ve found that the easiest thing to do is take my medicines at the time I would take them at home until I have got over the jet/travel lag and then slowly reset to the time zone I’m in by a couple of hours a day.

For short haul stuff, a couple of hours, it doesn’t seem to matter. It means keeping two watches but it works for me.

I take a lot of various medications including injections so I find that it’s important to be disciplined.

[Soundofman20]

I take my apixaban at same time in morn round 9am and between 8pm and 9pm at night i have even taken all my pills at 5.30am when i have to go for red eye flight makes no difference to how the meds work . I had cardioversion 2 yrs ago but sadly never lasted so had OHS 8wks ago and pacemaker 7wks ago . And you mustn't miss a dose of ur blood thinner until they tell you to stop .

[HamishBoxer]

An hour early is not a problem or ditto late, hospital told me an hour early when I had a Cardioversion.

[Catlover1981]

The medication will already be in your system. The nurse meant don't miss a dosage meaning don't miss full days but don't worry about clocks changing

[Parya in reply to Catlover1981]

Yes I received a letter yesterday outlining this and also checked with local pharmacist who said an hour out is fine, it's my first cardioversion so wanted to make sure thank you

[Catlover1981 in reply to Parya]

Good luck. I hope you get back and stay in sinus rhythm