Any one else?

[didntexpectthat]

10 months on from my STEMI. Heart doing fine, but for the last 7 months tired and nauseous most of the time. On statins, aspirin, clopidogrel and omeprazol. Looking at my digestive system to see if any cause there....I think its my statins bur that's the last thing they want to change. Anyone else in the same boat?

[Hidden]

I have taken Atorvastatin for over 20 years and am now on 80mg, a PPI for over 15 years including several years at the max dose, daily low dose aspirin, as well as Clopidogrel for a year a few years ago. I have also taken two other meds for over 15 years. And am fortunate that I have no noticeable side effects. However if you take dispersible aspirin, try gastro resistant which may be better for your stomach . That's what I do.

[didntexpectthat]

Thanks for the reply..on 80mg at moment. I know its still relatively early and waiting on other tests. Its interesting following your feed (thanks)...id love to get back to doing what I was before, or just being able to do things without feeling crap after!

[sickandsore]

I’m on statins, aspirin and clopidogrel, the cardiologist has just put me on omeprazole, I find that omeprazole actually seems to be the main culprit of my gastric issues, it protects your gut from the effects of aspirin however can cause nausea and in my case also constipation ( which makes nausea worse!) I take powders daily for a bowel issue to help my body to have a poo, but notice since commencing omeprazole I’ve got s as really gripey tummy. But better than a guy bleed I guess.. talk to your GP as may be able to prescribe you something else or an anti emetic.

[richard_jw]

Could be interaction between Clopidogrel, aspirin and the PPI

"Concomitant use of clopidogrel and an NSAID (including low-dose aspirin) has been associated with impaired healing of asymptomatic ulcers[75] and disruption of platelet aggregation[76], with a consequent increase in serious upper GI events (OR: 7.4, 95% CI: 3.5-15)[77]. Histamine-2-receptor antagonists are able to decrease peptic ulcer or esophagitis in low-dose aspirin users[78]. Famotidine is a histamine H2-receptor antagonist that is well tolerated and able to prevent and heal peptic ulcers in patients who are receiving conventional NSAIDs[79,80]. The FAMOUS trial (Famotidine for the Prevention of Peptic Ulcers in Users of Low-dose Aspirin) was a randomized, double-blind, placebo-controlled trial, which demonstrated that famotidine prevented gastric and duodenal ulcers, and erosive esophagitis in patients taking low-dose aspirin (i.e. 75-325 mg)[81]. Concerning the long-term use of PPIs, an alternative management strategy has been proposed, including the use of H2-receptor antagonists[81,82]. In other words, H2-receptor antagonists such as famotidine might be considered as a useful alternative in patients with drug interactions between clopidogrel and PPIs."

The source is ncbi.nlm.nih.gov/pmc/articl...

Bottom line is that Famotidine is effective as an alternative to a PPI such as omeprazole in preventing/healing peptic ulcers

It seemed to work in my case. The (very good) cardiologist changed me from Lansoprazole to Famotidine which is not a PPI

Hope this helps

[didntexpectthat in reply to richard_jw]

thanks for the reply. I was moved from Ticagrelor to clopidogrel about a month ago because of my symptoms. Im having an OGD next week hopefully and then a MRI. I need to start more exercise, but at the moment anything more than a walk and im nauseous...heart function is fine...guess I just have wait on the results