Nicotinamide Pathway-Dependent Sirt1 Activation Restores Calcium Homeostasis to Achieve Neuro- protection in Spinocerebellar Ataxia Type 7
pubmed.ncbi.nlm.nih.gov/318...
I'm just about to walk my dogs so this post will be short. The article above is behind a paywall, but I purchased it and will share it with anyone who asks. Long story short the study is saying what I have been saying for years. The fact that NIAGEN boosts Sirt1 activity is key, and that fact separates Niagen from all other forms of vitamin B3 which are Sirt1 inhibitors, AND Niagen is likely helpful for many, many central nervous disorders, AND this activity is due to Niagen's ability to dramatically boost NAD+ production in humans.
One interesting fact from this study was that although they actually tested Niagen in mouse models of SCA7, they also tested human brains (post mortem) for signs that what they were seeing in mice as the problem that was fixed by Niagen did in fact occur in humans as well.
Anyways, more later.
Cheers,
Joe in NY