I am sharing information, but as always no one should ever start taking something based on the comments of a stranger on the internet and you should always talk to your doctor before trying anything new!!
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Last year when I joined Health Unlocked I had just discovered trehalose and wanted to share my information. Now almost a year later I'd like to provide a type of summary to all that I have learned over the last many months. I also want to add a couple tiny updates. First, my father, the news is tragic, but informative. He suffers from Alzheimers as well as SCA1 so he reached a point where he could no longer stay independent and we, the family, made the choice to move him to a nursing home. Now over the last year his speech had held steady and he continued to take a few steps with a walker and use the bathroom unassisted. Essentially his SCA did not progress for 11 months. The nursing home he went to will not allow him to take trehalose and niagen and pterostilbene because they are not medicaid approved medicines. Within one month of stopping those supplements he started falling when he would try to go to the bathroom and his speech is now almost unintelligible. Were the supplements working? I have no scientific proof, but I and my family believe so. My aunt continues to take them and her symptoms have also held steady and she is still using a walker.
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Anyways, that's the update now here's my synopsis of what I learned this year.
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Using a multi-pronged approach to neurological disorders:
ncbi.nlm.nih.gov/pmc/articl...
youtube.com/watch?time_cont...
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Real world examples of people delaying Parkinson's:
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Diet and neurological health:
youtube.com/watch?time_cont...
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Exercise:
jamanetwork.com/journals/ja...
journals.plos.org/plosone/a...
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Trehalose (enhanced autophagy of misfolded proteins):
pharmacychoice.com/News/art...
academic.oup.com/hmg/articl...
link.springer.com/article/1...
link.springer.com/article/1...
jbc.org/content/285/43/3325...
sciencedirect.com/science/a...
link.springer.com/article/1...
scienceofparkinsons.com/201...
sciencedirect.com/science/a...
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one clinical trial of oral trehalose:
ncbi.nlm.nih.gov/pmc/articl...
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An older study that shows that sugar molecules nearly identical to trehalose pass thru the stomach wall undigested at a rate of 0.5 to 2%:
researchgate.net/publicatio...
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Niagen (cellular repair):
nature.com/articles/s41514-...
researchgate.net/publicatio...
sciencedirect.com/science/a...
ncbi.nlm.nih.gov/pmc/articl...
cell.com/cell-metabolism/fu...
cell.com/cell-metabolism/fu...
ncbi.nlm.nih.gov/pmc/articl...
ncbi.nlm.nih.gov/pmc/articl...
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Pterostilbene (NrF2 activation):
scienceofparkinsons.com/201...
sciencedirect.com/science/a...
sciencedirect.com/science/a...
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Thiamine (improved cellular energy usage):
healthunlocked.com/ataxia-u...
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PQQ (increased mitochondrial health)
healthunlocked.com/ataxia-u...
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vitamin D (neurological protection and general health):
ncbi.nlm.nih.gov/pmc/articl...
ncbi.nlm.nih.gov/pubmed/265...
health.harvard.edu/blog/vit...
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I want to emphasize that I had symptoms including: inability to stand on one foot, difficulty walking downstairs, difficulty with clear speech, diminishing handwriting, fatigue, and inability to use exercise to increase strength or endurance. All my symptoms are now gone and I am gaining strength and endurance again. Here is what I am doing:
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EDIT: I will update this list whenever I make a change and post change date:
latest change: 2/5/2018 - increased pterostilbene by 50 mg, added 300 mg benfotiamine, 20 mg PQQ, and B complex vitamin by Natures Way. Why: In theory thiamine helps cells utilize energy and increases cellular survival. The human trial of PQQ hinted at increased mitochondrial health which was shown in animal research. Pterostilbene at 125 mg a day lowered blood pressure, and thiamine seemed to increase mine so I thought I'd increase it and see.
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1) treadmill running 4-5 times a week for 30 minutes at 80% max heart rate followed by 10 minutes cool down
2) a diet mostly vegetarian with little or no dairy, processed food, sugar or meat and rich in cruciferous vegetables
3) supplements: 40g trehalose in 2 cups of coffee, 3 squirts of trehalose infused water per day in my nose, 500 mg of niagen twice daily, 100 mg of pterostilbene once daily, 2 cups of green tea daily, 2000 IUs of vitamin D, 300 mg daily of benfotiamine, 20 mg daily of PQQ, a vitamin B-complex vitamin from Natures Way.
4) yoga 3 times a week
5) meditation weekly
I would also note that I am currently researching and will likely add a thiamine supplement benfotiamine:
ncbi.nlm.nih.gov/pmc/articl...
ncbi.nlm.nih.gov/pubmed/275...
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Joe in NY