A lack of oxygen in tumors promotes metastasis.

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Metastases are formed by cancer cells that break away from the primary tumor. A research group at the University of Basel has now identified lack of oxygen as the trigger for this process. The results reveal an important relationship between the oxygen supply to tumors and the formation of metastases. This research may open up new treatment strategies for cancer.

The chances of recovery significantly worsen when a tumor metastasizes. Previous research has shown that metastases are formed by clusters of cancer cells that separate from the primary tumor and migrate to new tissue through the bloodstream. However, thus far little has been known about why these clusters of circulating tumor cells (CTCs) leave the tumor in the first place.

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Cell Reports:

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