Neuropilin-2b facilitates resistance to tyrosine kinase inhibitors in non–small cell lung cancer.

[2greys]

Medical University of South Carolina.

Neuropilin-2b facilitates non–small cell lung cancer resistance to tyrosine kinase inhibitors, and this biological effect relates to AKT activation. Neuropilin-2b GSK3β interactions appear to be essential for PTEN degradation and AKT activation in lung cancer cells. Disruption of the neuropilin-2b GSK3β interaction may represent a novel treatment strategy to preserve sensitivity to tyrosine kinase inhibitors in non–small cell lung cancer.

jtcvs.org/article/S0022-522...