Compounding & HyproMellose

[findtheanswernow]

I have asked a compounding pharmacy to make something equivalent to ibuprofen and Zyrtec - without Propylene Glycol. When I went to pick it up I discovered they had used HyproMellose as the filler. The pharmacist is telling me they contacted the manufacturer, that it is plant based and "should be" okay. I've always heard that HyproMellose contains PG. Does anyone have information to share with me on this? Also, if anyone has had an ibuprofen or zyrtec substitute compounded, can you please tell what they used as a filler?

[kerrykuzak]

I believe hypromellose is a PG ether. I get acetaminophen compounded without ANY fillers. Don't know if they can do that with ibprofen. I usually use more natural products (like tumeric) for pain/inflammation. I have not had allergy symptoms since I cut out dairy entirely and consume very little sugar. thefeelgoodlab.com/blogs/th.... I'll link an article below.

[kerrykuzak]

steptohealth.com/7-natural-...

[gothchiq]

Hypromellose is PG and wood pulp. Not an acceptable substance for us. Surely they can use some kind of binders and fillers that existed before all this glycol nonsense, such as potato starch (that's in my estrogen pills) and vegetable glycerin.

[gothchiq]

you can show them this to prove it. HPMC *is* hypromellose. sciencedirect.com/topics/nu... Hydroxypropyl Methylcellulose

Hydroxypropyl methylcellulose (HPMC) is mixed alkyl hydroalkyl cellulose ether containing methoxy and hydroxypropyl groups. It is prepared by reacting alkali treated cellulose first with methyl chloride to introduce methoxy groups and then with propylene oxide to introduce propylene glycol ether groups. Among the cellulose derivatives, HPMC has been extensively employed because of its ease of use, wide availability, superior film-forming capability, good biocompatibility and biodegradability. It is usually used in the pharmaceutical industry as a drug delivery matrix (film or gel) and in the food industry as a film former, emulsifier, stabilizer, or thickening agent. HPMC is a nonionic and water-soluble polymer (Rogers, 2009); this is of great importance as a carrier in drug release systems, including SDs (Lima et al., 2015) (Fig. 15.4).