Genetics, Inflammation and Some LifeHacks

[Barny12]

Some good info here - saffron anyone?

geneticlifehacks.com/atrial...

"Chronic inflammation is thought to play a causal role in atrial fibrillation. People with rheumatoid arthritis or psoriasis are at a 40% increased relative risk of atrial fibrillation. Both of these autoimmune diseases cause inflammation as well as abnormalities in the way that the electrical activation occurs in the atrium.

If the inflammatory signals aren’t resolved, fibrosis can occur in the heart muscle tissue. This remodeling of the heart muscle can be a cause of AF by changing the way the signal is conducted or changing the initiation of the signal from the autonomic nervous system.

What many people overlook is that the resolution of inflammation is an active process that relies on specialized pro-resolving lipid mediators. These pro-resolving mediators are synthesized from DHA and EPA, (Omega 3) which are lacking in the modern diet.

Resolvin D1 is a pro-resolving mediator derived from DHA that is key in resolving inflammation in the heart. An animal study showed that supplemental resolvin D1 limited atrial fibrosis and the changes to the heart substrate that cause AFib."

Supplements/vits recommended:

Magnesium

Potassium

CoQ10

N-acetylcysteine

Vitamin C

EGCG

Saffron

[Hidden]

Please remember to check with your GP or Pharmacist before taking any over-the-counter medicines, supplements, or herbal remedies, as they may have interactions with other medications.

Katrina.

[baba in reply to Hidden]

Well done. The post makes no sense now without the link.

[Barny12 in reply to Hidden]

Sorry I didn't realise there was a problem with getting links approved. Can you check and approve please?

[BenHall1]

Hi Barny,

Sorry if I'm a bit thick BUT - Admin say a link has been removed then there is a whole lotta stuff in italics ............. is what is in italics the link or just part of what you originally posted anyway.

Doesn't make that much sense ? It needs some better context.

[bean_counter27 in reply to BenHall1]

And we need to know where this extract came from. I searched for sections of the text, without success. I found other information about the potential link between inflammation and AF but in the articles I read it was uncertain whether there was a causal link between the 2 and if there was, which one is a cause (or contributory cause) of the other.

Certainly an interesting area but I would advise everyone against "knee-jerk reactions" to snippets of information on the Internet. I regularly watch shows on YouTube where supposed doctors have totally different views about the causes and remedies of a variety of conditions. The same can be said when Googling information on the Internet. There's nothing wrong with doing so IMO. However, it should largely just extend to arming yourself with information and about your health issues and possible treatments so that you can engage your GP or specialist about the way forward i.e. don't start/stop/adjust dosage(s)/change your medications/supplements without consulting a medical professional.

In addition, a forum member recently brought to our attention the prevalence of bogus medical papers on the Internet - even on respected sites. So keep that in mind.

[Hidden in reply to bean_counter27]

I don't think there's any doubt that inflammation can exacerbate or trigger AFib.

[bean_counter27 in reply to Hidden]

But does it cause AF i.e. people get AF because of some form of inflammation? If so, why don't they treat the inflammation - or is it too late, the damage is already done?

[Hidden in reply to bean_counter27]

I can't say that it causes AF but it definitely can trigger AF in someone who already suffers from paroxysmal AF.

[Barny12 in reply to bean_counter27]

I didn't know anything about needing to get links pre-approved - I must have missed the furore about that and have no idea how to get it approved now...but this is the latest article from Genetic Lifehacks.

[Auriculaire in reply to bean_counter27]

Most coventional doctors know zilch about supplements or herbal products. They have no training in this at med school and are more likely to pooh pooh them as being useless . Consulting them would be in most instances a waste of time given that getting time with a GP for anything can be so difficult these days. How many would even have a clue what ECGC or NAC were?

[Broseley in reply to Auriculaire]

I so agree. My GPs know very little about the prescribed drugs I take never mind supplements. Ditto hospital doctors. Both my gastro and rheumy showed no interest whatsoever in my list of supplements I gave them.

[Auriculaire in reply to Broseley]

My granddaughter's aunt is a doctor - a pulmonary consultant . She is in her mid forties. She told my granddaughter that at med school they were not really taught about delving into underlying causes for diseases just what drug to prescribe for a disease.

[Broseley in reply to Auriculaire]

I recently asked for a medication review at the GP, as I'm on 7 prescribed drugs (was 8). I wanted to query my prescription for some of them and the supplements I take. I was given an appointment with a nurse, who measured my weight and blood pressure and did blood tests. I was told that was my medication review! I protested and got a GP appointment. He was totally useless but agreed with me about everything and took me off alendronic acid as I only have a T score of -1.1.

I requested an appointment with the surgery pharmacist. He was really helpful. He spent over half an hour going through all my meds, advising me about supplements and timings of when to take each drug to avoid interactions. He changed me to edoxaban from apixaban, and changed my calcium tablets to one that was easier to take. He upped my dose of atorvastatin due to my cholesterol levels being on the cusp of too high - he explained that the parameters have changed. All in all, a very satisfactory consultation.

[Hidden in reply to Auriculaire]

Spot on.

Symptoms...click click whirr....out pops a prescription. We would honestly be better off with an AI treating us, which would be easier to keep up to date and be able to collate all the information of our medical history, meds we're on etc.

Which is absolutely not to disrespect doctors. I have a brilliant GP surgery and don't have a bad word to say about them. It's just the system they're operating within.

[LaceyLady in reply to Auriculaire]

🤦🏼‍♀️🤦🏼‍♀️🤦🏼‍♀️ drug companies rule. Also one dose fits all, never mind that women and men are vastly different!

[BenHall1 in reply to Auriculaire]

Yeah Auriculaire .... right on there ...... you want to see my GP roll her eyes ( back in the day when you could get a face to face appointment ) ..... fits somewhere between worrying and horrifying 😱😱😂😂 !!

[Barny12 in reply to BenHall1]

I didn't know anything about needing to get links pre-approved - I must have missed the furore about that and have no idea how to get it approved now...but this is the latest article from Genetic Lifehacks.

[BenHall1 in reply to Barny12]

Thanks Barny. I'll pursue that article ..... something to do next week when its half term and the weather is rubbish and I'm not working. Must admit I have no idea either, so now I just don't bother if I have a link.

[Hidden]

For anyone interested, I just watched a Dr Gupta video on YouTube just this morning talking about Vit C and some interesting studies about how it can potentially help Afib. Just look for York Cardiology channel on YouTube - the video was posted 2 years ago.

[LaceyLady in reply to Hidden]

I have Haemochromatisis no to vitamin C!

Also there’s a link with arrhythmia

[Hidden in reply to LaceyLady]

I'm guessing you meant 'I have haemochromatisis' in which case, I'm sorry to hear that and yes, Vitamin C is contraindicated.

I'm not sure what you mean about there being a link with arrhythmia though? Dr Google throws up numerous respectable sources - in addition to our much loved Dr. Gupta - saying that Vitamin C can be beneficial for the heart as well as many other things.

Do you have sources?

[LaceyLady in reply to Hidden]

Haemochromatosis has links to arrhythmia

[Hidden in reply to LaceyLady]

Oh okay, gotcha

[TracyAdmin Partner]

Hello Barny12

Please can you approach Admin via the Chat button to gain consent for approval of any external links.

Thank you for your understanding. You will find a the Forum Guidelines, available to view from the 'pinned posts'

Kind regards

TracyAdmin

[Barny12]

Link now back up!

geneticlifehacks.com/atrial...