Edoxiban

[IBStired]

I have had absolutely no problems with taking this med. Sooooo much better than taking Warfarin.

[Hidden]

Just taken a peek at your previous post which was far more interesting 😂.

Over the years, I guess Warfarin has saved many lives and there are many here who would probably never take anything else, not least the over worked and underpaid volunteer and favourite ex Antipodean bus driver. Although I took it when first diagnosed, I was happy to change to a DOAC mainly because it made travelling abroad much easier. We get lots of good reports from people who take Edoxaban and no doubt if it had been prescribed for me I would have been happy to stay with it…..

[Thomas45]

Several years ago I was having problems with stabilising my INR, the clotting rate of blood, and was tried out on Rivaroxaban. Within hours of taking it, I had pains throughout my body, everywhere except my head.I phoned a GP who said what I expected him to say, to give it time, the pains will wear off. They didn't. On the 12th day I had an appointment to see a GP. At that stage I needed a stick to help me walk. Once I'd sat down, I couldn't get up. I decided that I wouldn't take any more Rivaroxaban. I was given pain killers, and started on a series of blood tests. The Erythrocyte Sedementation Rate test should have had a result of 20, which is the rate of a normal man at my age then, showing no inflammation. The actual result was 130, showing a high amount of inflammation. Diagnosed as having Polymyalgia Rheumatica, an auto-immune condition. My body didn't like the Rivaroxaban.

I went back to Warfarin, and bought myself some test strips, lancets, and a Coaguchek XS meter. I was able to get into range of INR by checking my INR when I wished.

I was pleasantly surprised to find that the GP would supply test strips and lancets on prescription. My medical record was marked "No NOACs".

Just recently I've had two readings out of range on the high side, one at 4.1, and the other 3 weeks later at 3.7. I adjusted my dose accordingly.

My arrythmia nurse wants me to try another DOAC. It took me 4 years to get rid of Polymyalgia Rheumatica. I don't want it again.

I've felt a reticence to allow me 24 strips at a time, so I recently bought myself a box of 24 strips. Warfarin works for me. The "aban" DOACs work for others.

[Cavalierrubie in reply to Thomas45]

I can’t tolerate any of them either Thomas. Made me very sick trying. Warfarin is the only anticoagulant for me. Good you are checking your INR yourself and getting accessories free from doctor. I would like to do that myself but keep putting it off because the machine is so expensive. Anyone got a second-hand one to sell? All the best.

[ozziebob]

Here's some recent German research that should give you confidence in your choice ... pubmed.ncbi.nlm.nih.gov/347...

[Threecats in reply to ozziebob]

Interesting, although I can’t help noticing that several of the study authors appear to work for Daiichi Sankyo , the manufacturers of Edoxaban🤔

[ozziebob in reply to Threecats]

This was a retrospective cohort study of a databank of 3.5 million patients. Are you suggesting the authors might have "fiddled" the numbers to give results favourable to the "employers" they "appear to work for"? 🤔

I admit I didn't have access to the full 2021 article or the details you reported, but such obvious manipulation of data would be contradicted by other research over time. Hopefully.

I haven't seen such negative results re Edoxaban yet. Have you?

[Threecats in reply to ozziebob]

I’m not “suggesting” anything. It was merely an observation that I thought worth mentioning. If you click on the “show details” button beneath the study title in the link you posted, you will see that it reveals the authors and their various affiliations.

Coincidentally , I’m currently reading a book by Stuart Ritchie called “Science Fictions”. Quite an eye-opener when it comes to discussing matters such as bias in studies, amongst other things. An interest book that might well be worth a read, if you have time, given your apparent faith in the veracity of research studies!

In response to your last question, I’ve not studied Edoxaban in any detail myself yet, so cannot answer, I’m afraid.

[ozziebob in reply to Threecats]

Yes, I thought I was sharing some "good news" with IBStired , but you are right to be cautious of all such individual research results re DOACs, which could be outliers and potentially misleading.

But in this case I'm hoping Edoxaban really is "good news", especially for those who have been unwillingly switched to Edoxaban, and all the new AF patients who are now offered Edoxaban as the first choice anticoagulant (unless there are other mitigating medical factors). 🤔

[Threecats in reply to ozziebob]

Hopefully you are sharing “good news” and it’s certainly pertinent to flag up such a study given the current drive to switch folk to Edoxaban, as you say. I’m certainly not saying the study is flawed, just that it’s worth keeping in mind that at least some of the study authors might perhaps be considered to have a vested interest in promoting Edoxaban above other DOACS and Wafarin.

[IBStired in reply to ozziebob]

Ok, not sure if you are commenting on my reply but I don't work for any connection to this drug, Edoxaban. I just find it is easy to take, does not upset my stomach etc and is so freeing from the carefuly watching eye when taking Warfarin.

[ozziebob in reply to IBStired]

Yes, my original Reply was addressed to you. I was simply referring you to some German research that gave Edoxaban the best results of all anticoagulants for preventing strokes and brain bleeds. What's not to like.I hope you read the article.