Looking for some hope.

[Justgettingitright]

Dad was diagnosed with Prostate cancer stage |V B in February 2024. Distant bone Mets. Doctors did not feel the need to do triplet therapy and did bilateral orchidectomy instead. He was on doublet therapy and started abireterone +pred which worked for 5 months and PSA started to increase.

He received Apceden vaccine in Nov’24.

PSMA pet scan showed disease progression and he started chemotherapy - docetaxel +Carboplatin in Dec 24. Enzalutamide was added after 6 cycles when PSMA pet scan showed mixed response of chemotherapy.

PSA is still increasing and has reached 37. Nadir was 0.14 in August 2024.

My dad is asymptomatic. He has no pain, no loss of appetite, no fatigue nothing. He had no side effects from chemo as well. He is still working, driving and living life as usual.

Don’t know what to do next. One side I am happy that he has no issues clinically but the PSA and scans are reflecting something else. MO is not being helpful and wants us to continue with chemotherapy which clearly is not helping. Please help with treatment options that can be helpful.

[GP24]

Another therapy with fewer side effects than chemo would be Lutetium 177 or Pluvicto. If you combine that with Enzalutamide, it will work better. This Lutetium 177 therapy is available in India.

[Justgettingitright in reply to GP24]

MO believes that LU-177 won’t work as he has non PSMA avid lesions as well.

[Bronzee in reply to GP24]

You mean we can go to India for medical treatment? I wonder how much it costs there.. thanks for your input.

[GP24 in reply to Bronzee]

Justgettingitright is from India and therefore I wrote this . Members of this forum went to India for this therapy.

[God_Loves_Me]

may be

Pfizer’s TALZENNA® in Combination with XTANDI®

Source : pfizer.com/news/press-relea...

[Justgettingitright in reply to God_Loves_Me]

Thank you for sharing. I will ask my MO about this.

[Tall_Allen]

Is Xofigo available in India?

[Justgettingitright in reply to Tall_Allen]

Thank you Tall_Allen . I will raise this with our MO. We are visiting TMH at Mumbai for another consultation. Il bring it up with the oncologist.

[Lettuce231]

Can you get a second opinion 🤔

[Justgettingitright in reply to Lettuce231]

Yes. That’s next for us. We are going to TMH at Mumbai for another opinion.

[Lettuce231 in reply to Justgettingitright]

I would, I wish you well

[j-o-h-n]

Remember his hope is to be around to see his beautiful Grandson getting his PHD...And he will....

Good Luck, Good Health and Good Humor.

j-o-h-n

[Justgettingitright in reply to j-o-h-n]

That’s what we are all hoping for, John! Just trusting his instincts and positive outlook.