You who still have your prostate. What is your lowest psa when in/after treatments?

[petrig]

Ihave my prostate.Starting psa was 2500 . After 6 months (in triplet therapy Firmagon+Doce+Nubeqa,last doce 29.2.2024)in end of July 2024 psa was 0,4.Next psa testing in march 2025.

[Prelki]

I don’t know whether it is fair to compare PSA results on different meds or not, but my husband was diagnosed May 2024 with a PSA of 315 and immediately started on Lupron joined by Abiraterone and prednisone starting July 2024 after 5 radiation treatments to T-11 and 12. Also having monthly infusions of Zometa for the bone mets. His PSA as of December was 0.06.

We are planning a trip to Finland - looks like a beautiful country. Hope the medical care for you is great as well.

[petrig in reply to Prelki]

Medical care here in public healthcare is great.You get the best treatments almost free. For example Nubeqa costs are only 4,5€/month. Doctor appointment in hospital 66€ or 38€ in health-care center.Finland🇫🇮 is beautiful and peoples friendly and honest.Welcome

[Prelki in reply to petrig]

That’s great to hear. Very glad for you. Yes, we’ve read that the people are friendly, almost 100% literacy rate (fantastic) and I’ve seen that Finland is the happiest country in the world! Sounds excellent! Looking forward to it and thank you. 😊

[NemoHic]

My PSA is below 0.1 but started nearly 200 times lower than yours despite "extensive metastases". You have a much better than 99% reduction, which is one of the criterion used to gauge excellent response. (In fact, much better than 99.9% response!) I personally wouldn't worry too much about a couple residual tenths.

[ARIES29]

Good luck to you Petrig. I can not get the PSA below 0.69 on Zoladex 3 month & Nubeqa every day.

Finland sounds like a nice place, we could do with meating nice people for a change.

[Huzzah1]

PSA at time of Dx was 3.5. Gleason 9 with 3 lymph mets in pelvic region. 44 rounds of IMRT - 2 years Lupron and Abi. Last injection was April '24. PSA has remained undetectable.

[garythomas]

<0.02

[TheLarch]

PSA 150 just over a year ago. On Apalutimide, Megestrol and Lupron. 6 weeks radiation (IMRT) and have been holding at 0.02 PSA since last spring. One more year to go of ADT!

[Gimmishelter]

Still holding onto my prostate. Diagnosed 2 years ago with PSA12 and 4 bone mets. Been on Lucrin/Abi since then and my latest monthly PSA is 0.087.

[petrig]

I think if you have prostate left(you dont have prostate removal surgery )how can your psa be undetectable?

[Jpburns in reply to petrig]

Mine is undetectable, after radiation and currently taking Orgovyx.

[vintage42 in reply to petrig]

"... if you have prostate left (you dont have prostate removal surgery ) how can your psa be undetectable?" Because hormone therapy suppresses the cancer cells that make PSA. I had cancer remaining in my radiated prostate, and it was growing larger in there, until I began hormone therapy. , The prostate and the cancer are still there, but the PSA is 0.01.

[85236442968 in reply to petrig]

Petrig

I still have my prostate, (my older brother had his taken out in 2013, and I thought it was just brutal) I was diagnosed in Oct of 2023, so 15 months of Lupron/Abiraterone/Prednisone and 28 rounds of IMRT on pelvic area. ending right about a year ago. My PSA has been at 0.04 since Jan of 2024.

Also had 3 lymph nodes in periaortic region that got 3 rounds of SBRT.

The original plan was 2 years of Lupron + Abi/Pred, then just Lupron or Elligard for an undetermined time.

Best wishes on you journey.

[Huzzah1 in reply to petrig]

My treatments being Oligometastatic was set Lupron - Abi - Pred. 2 years. Also 44 rounds of IMRT. My local MO and my MO at MD Anderson are hopeful that I have a more than 65% chance of a cure. So yes the prostate is still there but it has been crushed due to the treatments. My T is also still undetectable a of Oct, my next blood work is in 2 weeks.

[Golfnerd]

6 years ago, 04/2019, PSA 2250. Bone and lung mets. No surgery, no radiation. Lupron, Abi, Prednisone. Within 3 months PSA<0.05. Stayed on the same regimen until 10/2023. Now off all meds for more than a year. PSA still <0.05. I am lucky and happy at age 81.

[Pjford in reply to Golfnerd]

That’s contrary to everything I’ve been reading for 9 months . I’d be curious if anyone on here had same treatment? My PSA 25 , low volume in pelvic and Lymph nodes . Treatment 28 rounds Radiation/ ADT for two years ? My PSA currently0.14

[Dont08759]

inoperable PC due to lower anterior resection and 5880 rads of radiation 30 years previous for rectal cancer. When on Lupron and Orgovyx PSA goes to 0.03 and T=6. Highest non-ADT PSA = 7.1

[PCASURVIVOR]

I was diagnosed in 2021 - Gleason 9, 4+5. I took part in a clinical trial involving a six month trial of Lupron, Xytiga/Prednisone and Niraparib. SBRT was administered at the midpoint of ADT treatment. PSA was 16 at beginning of treatment; fell to undetectable after SBRT. Was detectable at 0.01 at month 4. I am now at 30 months following conclusion of treatment and involved in twice annual visits with clinical trial team. PSA was .06 in December; testosterone has returned to normal levels. I am 73-1/2 years old.

[Diana2727 in reply to PCASURVIVOR]

Great story! Congrats!

[Jsbach1953]

Well, the "normal" range for a healthy prostate is 1 - 4., so I'm not sure the artificially induced low PSA is necessarily ideal (though I'm sure it's better than a high PSA!). My oncologist said, "If you have a prostate gland, you're going to have some PSA. Reducing it to near-zero isn't realistic." That seems quite different from what I'm reading here.

[Mgtd in reply to Jsbach1953]

I agree with your general statement and in fact that is printed on every PSA test results along with a PSA range based on age. This assumes a prostrate and NO hormone therapy.

HOWEVER when you are taking ADT you are stopping the normal flow in the hope of either killing or slowing the disease progression so that is why the non ADT numbers do not apply.

Hope that helps.

[4tunate1]

This time last year my PSA was 386. Started Lupron/Abi+prednisone, 10 rounds of radiation to T2 & L2. PSA dropped super fast and has been undetectable since May. Actually getting a blood draw today so wish me luck!

[Hobierat]

new nadir 4 years post treatment 0.1

[leo2634]

My only treatment since diagnosis Feb 2018 has been Zytiga Prednisone Eligard Provenge infusions in 2019 and my PSA has been 0.1 ever since then. Never give up never surrender Leo

[dhccpa]

I hit 0.5 four years ago but that was using only Lupron, not doublet therapy (which I still haven't used.

[Tommyj2]

still have my prostate and last test psa was undetectable….prior to that it was .01

[johnscats]

Stage 4 numerous mets psa was 465 when I discovered I had it adt firmagon lowest was 1.3 1.4 has gone as high as 6.58 but drops to around 2.5 again 7 years now scince I got the little creep

[Bspouse in reply to johnscats]

What did you do to get the PSA to drop after it rose to 6.58 or did it just go back down over time?

[johnscats in reply to Bspouse]

I take mebenzenole curcumin cbd oil all the time as well I'm not saying they have anything to do with it as I'm on them when it goes up but it just drops again sometimes quickly other times over several months my bloods are done here every 4 weeks had ct scan with contrast start of December no change even my oncologist can't seem to figure it out they had a meeting about me last week a group of them together not just me other cases as well so waiting for an appointment was supposed to be next Monday but no letter of appointment yet hope this helps and things work out for you

[johnscats in reply to Bspouse]

Oh sorry forgot to say I have it 7 years now for the last 5 it's been acting like this

[Chewiemo]

diagnosed 2 1/2 years ago stage 4 with multiple bone Mets and psa of 87. Triplet therapy of Lupron, abi with Prednizone and zytiga. For last 20 months psa and T undetectable. Still have prostate which shrunk dramatically.

[fast_eddie]

My PSA was only 2.7 when diagnosed Gleason 8. It was undetectable (less than 0.1 at the lab I use) after a six month eligard shot and HIFU full gland ablation. I had that surgery 8 years ago. It has since ticked up to 3.2. I was put on dutasteride which knocked it down to 1.3. I am now using dutasteride intermittently. I have PSA checks every four months now. I am 74.

[32Percenter]

Upon diagnosis my PSA was at 104. After triplet therapy using Docetaxel x 6 infusions, Zoladex every 3 months, and Nubeqa daily, it was at 0.0 6 months later. So I'd say the answer to your title question is ZERO, but it all depends on how your particular PCa cells respond to androgen deprivation.

I notice many on this thread quoting PSA values with 3 decimal spots (i.e. 0.003). Ultra sensitive tests are nice to have, but with a prostate still in your body you're going to have SOME fluctuations in the numbers, especially if there are still some low levels of testosterone in your system. So such tests might lead to unnecessary anxiety.

[TuffNuttoCrack]

sorry to say I still have that seed planter. PSA always reported out at less than 0.1.

Moments ago my oncologist said it’s been zero whatever that means for last two years. On Abby and Lupie only.

[j-o-h-n]

My wife took mine using a pair of Fiskars, and it now hangs around her neck in a beautiful 14kt gold plated Kalevala necklace.....But I'm lucky cause she left me my "Pallo" and my "Kulli".

Good Luck, Good Health and Good Humor.

j-o-h-n

[TuffNuttoCrack in reply to j-o-h-n]

John there you go again,.,,, using words that aren’t even in the unabridged dictionary,

[j-o-h-n in reply to TuffNuttoCrack]

You're right again.......... Sorry, it's just a kuirk of mine...

Good Luck, Good Health and Good Humor.

j-o-h-n

[Kaliber in reply to j-o-h-n]

LMAO ….. you weapon sounds “ well honed “ today my brother. Great stuff.

😁😁😁

[j-o-h-n in reply to Kaliber]

Stop with the praise again........... otherwise people will think we're conjoined at our lip twins...

Good Luck, Good Health and Good Humor.

j-o-h-n

[Kaliber in reply to j-o-h-n]

Oh, Sparkle plenty. My fault buddy , mine entirely. I forgot you don’t like to be recognized for the great “ edge “ you contribute while , often times, gently prodding/ guiding posters to more data and/ or details….. supporting the group.

I’ll try to remember next time …. Sorry big guy

🤯🤯🤯

[j-o-h-n in reply to Kaliber]

You know I love you but I prefer money instead of praise.......Get the hint B. O.? (I too remember those comic strips).

🤯🤯🤯

Good Luck, Good Health and Good Humor.

j-o-h-n

[GAdrummer]

Best results "undetectable" after Keytruda.

[doc1947g]

I am 77 years young and had ADT(Lipton Depot) in 2020 (PSA 21.4μmg/ml.

Last PSA IN February 2024 was 0.03μmg/ml.

Nadir PSA=0.01μmg/ml.

[VictoryPC]

Mine went from 49 to .04 after 6 months of Casodex and Lupron. That was 14 years ago. Since then I've used natural ADT along with Casodex intermittently evey 3 months. I'm still here and never developed resistance. PSA is table under 4.0ng.

[CAMPSOUPS]

You got a lot of responses here. Mine is just another. Still have prostate.

My first walk into the doctor office PSA 1621, bone mets skull to ankles, lymphs pelvis to neck. (November 2019)

Triplet therapy was just around the corner but I couldn't get insurance approval in those days.

Started with Lupron, 6 infusions chemo.

10 months after last chemo infusion progression and started Zytiga. During the year Zytiga was working my PSA got the lowest its ever been these 5 years (1.2).

YOur doin good brother. Great treatment response. I think your on a good path.