CABAZITAXEL

[Jshaw916]

Cabazitaxel Question:

PSA Started at 81 ( over 60 bone metastases)

after 1st chemo dropped 11 points 70

after 2nd chemo it went up 20 points

Could this be chemo flare? My dad is also not taking daily prednisone because it messes with his blood sugar (he is diabetic) . He is going to start taking it now. Could that affect PSA@?

[Tall_Allen]

How soon after chemo were the PSAs taken?

[Jshaw916 in reply to Tall_Allen]

3 weeks. Just before next chemo given

[Tall_Allen in reply to Jshaw916]

Maybe ask for a CT or MRI to see if tumors are shrinking.

[Jshaw916 in reply to Tall_Allen]

I agree especially if it rises after 3rd. I’m wondering if adding carboplatin would help

[God_Loves_Me]

please update profile or bio

[Jshaw916]

just did

[God_Loves_Me in reply to Jshaw916]

Does he take zometa or other bone protection?

[Jshaw916 in reply to God_Loves_Me]

No he does not

[God_Loves_Me in reply to Jshaw916]

I copied Allens comment

Try adding Celebrex along with the zoledronic acid for an increase in survival of 22%. Send this link to his oncgist

ascopubs.org/doi/full/10.12...

As prostate cancer progresses, it sometimes puts out less PSA. Bone alkaline phosphatase is another biomarker for prostate cancer when it is in the bone