CABAZITAXEL

[Jshaw916]

Cabazitaxel Question:

PSA Started at 81 ( over 60 bone metastases)

after 1st chemo dropped 11 points 70

after 2nd chemo it went up 20 points

Could this be chemo flare? My dad is also not taking daily prednisone because it messes with his blood sugar (he is diabetic) . He is going to start taking it now. Could that affect PSA@?

[Tall_Allen]

How soon after chemo were the PSAs taken?

[Jshaw916 in reply to Tall_Allen]

3 weeks. Just before next chemo given

[Tall_Allen in reply to Jshaw916]

Maybe ask for a CT or MRI to see if tumors are shrinking.

[Jshaw916 in reply to Tall_Allen]

I agree especially if it rises after 3rd. I’m wondering if adding carboplatin would help

[God_Loves_Me]

please update profile or bio

[Jshaw916]

just did

[God_Loves_Me in reply to Jshaw916]

Does he take zometa or other bone protection?

[Jshaw916 in reply to God_Loves_Me]

No he does not

[God_Loves_Me in reply to Jshaw916]

I copied Allens comment

Try adding Celebrex along with the zoledronic acid for an increase in survival of 22%. Send this link to his oncgist

ascopubs.org/doi/full/10.12...

As prostate cancer progresses, it sometimes puts out less PSA. Bone alkaline phosphatase is another biomarker for prostate cancer when it is in the bone

[Jshaw916 in reply to God_Loves_Me]

Thank you

[spencoid2]

I will be starting Cabazitaxel next week and they are also adding carboplatin. Something to do with it maybe being better as I have CDK12 mutation.

When I did doxytaxal alone maybe a year ago my PSA went up and down during the cycles. It was explained that so many factors contribute to PSA level that PSA alone can not be used to monitor effectiveness of an ongoing treatment, alone.

[Jshaw916 in reply to spencoid2]

Thank you so much for your response. My dad had genetic testing and no mutations.

[speranza10]

You have to be patient, the psa can start to drop steadily even after 4 infusions of cabazitaxel. However what the scans will say is more important, I would do 4 infusions and then do some scans to really see what the cancer is doing.

[Jshaw916 in reply to speranza10]

Thank you. I’m hoping all we need is time

[j-o-h-n]

How old is your dear Dad and where is he located (city/state). Thank you.

Good Luck, Good Health and Good Humor.

j-o-h-n

[Jshaw916 in reply to j-o-h-n]

75, Chicago suburb IL

[j-o-h-n]

Thank you. You may wish to add this data to your Dad's bio. Give your Dad my regards and tell him I've got him by 13 years. Happy New Year to all.

Good Luck, Good Health and Good Humor.

j-o-h-n

[Jshaw916 in reply to j-o-h-n]

Thank you