I just wanted to share a piece of research I came across it involves Fisetin and Cabazitaxel.ncbi.nlm.nih.gov/pmc/articl...
I decided to act on this and take Fisetin when I started Cabazitaxel in October 2021
my oncologist was hoping for a drop of 50% on my psa over the course of treatment, after 4 cycles my psa has dropped from 28 to 9, how much is down to the Fisetin I can’t say. I do fast before chemo and train at the gym daily both of which could be helpful.
Knowledge is power, stay strong and stay safe.
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Mick268
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Fisetin is anti cancer flavonoid . Each one of man who has PCa should eat this flavonoid .I eat Straberries, other berries, Apples, Dark red grapes daily to get enough Fisetin. Almost all fruits have some fisetin in them.
Fisetin anti-neoplastic activity has also been assessed in multiple pre-clinical prostate and bladder cancer models. In a cellular model that used fisetin as a positive control, the IC50 of fisetin was 34.1 ± 7.7 μM as measured by WST-1 cells in LNCaP cell culture [52]. In mice, fisetin (1 mg/kg) intraperitoneally daily) significantly reduced both the tumor weight and size of the xenograft prostate tumors [53]. In another preclinical study, fisetin (10–60 μM) was associated with decreased cell viability in LNCaP cells (19–62%) and CWR22Rυ1 cells (18–55%) after 48 h treatment, with minimal effect on prostate epithelial cells at the same concentrations. Furthermore, this study showed that in nude mice bearing xenograft prostate cancer tumors, fisetin (1 mg/day intraperitoneally) was associated with an average tumor volume of 302 mm3 after 26 days treatment, compared to an average tumor volume of 1200 mm3 in controls [54].
"Fisetin (20 μM) has also been found to synergize with cabazitaxel (5 μM) in cellular models of 22Rν1, PC-3M-luc-6, and C4-2 prostate cancer cell lines [55]. In these three cell lines, a 45%, 49% and 74% decreased cell viability, respectively, was reported with fisetin alone while a 32%, 11% and 38% decreased cell viability was reported with cabazitaxel alone. This model showed that fisetin can synergize with cabazitaxel, as a combination of fisetin plus cabazitaxel yielded a reduction in cell viability by approximately 79%, 53% and 78%, respectively, in the three cell lines assessed. In nude mice bearing prostate cancer xenografts, the authors explored the effect of intraperitoneal injection of either fisetin (20 mg/kg; 3 times/week) alone, cabazitaxel (5 mg/kg; once/week) alone, fisetin (20 mg/kg; 3 times/week) plus cabazitaxel (5 mg/kg; once/week), or vehicle. Of note, while fisetin alone and cabazitaxel alone were associated with 22% and 31% inhibition of tumor growth, respectively, cabazitaxel plus fisetin yielded a 53% inhibition of tumor growth compared to the control group [55].
One of the possible mechanisms of action of fisetin may be mediated by decreased synthesis of ialuronic acid [56], as higher levels of ialuronic acid in the tumor microenvironment are associated with prostate cancer progression [57].
"Additional putative mechanisms of action of fisetin in prostate cancer include microtubule stabilization (10 μM) [58], inhibition of epithelial-to-mesenchymal transition (60 μM) via inhibition of YB-1 [53], TRAIL-mediated augmentation of apoptosis (50 μM) [59], inhibition of cell cycle (1–50 μM) [60,61,62], induction of autophagic cell death via mTOR suppression [63], and inactivation of the JNK and PI3K/Akt signaling pathways [64]. Fisetin may also favorably modulate gut microbiota [65], which is possibly involved in prostate cancer etiopathogenesis [66].
"Fewer studies have been conducted in bladder cancer models, although fisetin has also shown promising results as an anti-neoplastic agent in this tumor. In a bladder cancer cellular model, 60 μM fisetin was associated with an approximately 60% cell viability after 48 h in T24, EJ, J82 cell lines [67]. In a rat model of bladder cancer induced by intravesical N-methyl-N-nitrosourea (MNU) [68], fisetin + MNU yielded tumor occurrence in 22.2% of rates (4/18) compared to 70.6% (12/17) of MNU alone. This finding is consistent with the results obtained in another study showing that fisetin was moderately inhibitory to mutagenicity associated with benzidine, a human bladder carcinogen, in the Ames Salmonella microsome/mutagenicity assay [69], which provides proof of concept evidence supporting the use of fisetin as a preventive bladder cancer agent. Putative biological mechanisms of fisetin anti-neoplastic activity in bladder cancer involve apoptosis and cell cycle arrest via activation of p53 and inhibition of NF-kappa B pathway [67,68]."
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