I have been on Lupron and Abi since May 2022 and in March 2024 Psa bottomed out at 1.02 and immediately started climbing to where it is now at 6.74. My previous MO, who is now retired, said Xtandi would be next treatment. New MO says chemo because I am still strong and it is needed before Pluvitico which he says is a great drug. I am interested in gaining knowledge about se and whether or not it was effective for you. I would also like to know if you did BAT on your own or under a doctors care. My Uro is ok with my seeking info on BAT but MO is against it because it is not approved. I live 90 min drive from JHU wher Dr Denmeade is and where I can be tested to see if I am a candidate. My Uro is a friend of Denmeade and still teaches at JHU one day a week so I feel confident trusting him to guide me through this. As I said, I am gathering info at present and would only proceed if testing shows a possible benefit. Thanks and God bless, Gary.
Experience with BAT: I have been on... - Advanced Prostate...
Experience with BAT
my lay reaction is why would you consider BAT with rising psa? isnt it the kind of thing started off during undetectable psa so one takes a holiday from the adt, hopes psa stays flat, then re-initiates when it rises? rinse repeat?
The answer to your question is as a cancer patient I will consider everything and choose the treatments with the most benefits and highest QOL.
It isn’t what you just described. You described IADT. BAT kills cancer cells by hitting it with a high amount of T after the cancer has adapted to a low T environment. It can also resensitize the cancer to Xtandi or make it more effective if going on it for the first time.
oh, yeah. you are right of course.
I asked my MO about T supplementation and because my case is advanced very high risk, the answer is a flat no-go.
My MO refuses at this point because it is not yet approved. I reminded him that the drug I am now taking wasn’t approved when the first patients started on it. My Uro will be the one to treat me with BAT if in fact the testing shows I’d benefit and I decide to give it a try.
Have you read the patient's guide to BAT?
onlinelibrary.wiley.com/doi...
The test they've developed is based on genetic mutations so if they think you qualify it seems like it would be worth trying.
One thing I think they've pretty much determined is that Xtandi directly after Abi is generally ineffective. Xtandi after BAT is much more effective, even if BAT itself wasn't. I can dig out the links on the trials/info if you can't find them.
Thanks but I’ve read the info and watched the videos. I have a urologist I trust as much as any doctor I have ever had and was a Doctor for several years at JH with Denmeade.
Don't do BAT on your own-- it is dangerous.
Thanks TA. I am only gathering info at present and will not proceed without testing at JH. As I said my Uro is a friend of Denmeade and I live less than 90 min drive from JH. I meet their first two requirements which is no pain and no urinary symptoms. My Uro is going to discuss this with my MO and I’ll proceed after I get all opinions. Pretty sure both think I need another liquid biopsy and genetic testing again.
BAT Question
BAT & Abiraterone / Enzalutamide resensitization
Transformer study -Dr. Szmulewitz- BAT and Adaptive Theory 
