Docetaxel Kills Cancer

[alperk]

I have just completed 8 of 12 biweekly treatments and have happily watched my PSA drop steadily from 15 to 0.33. The weakening effects of the chemo have dampened my enthusiasm for working out, even walking. I read that docetaxel is the second most toxic chemo and can't disagree. My question, though, is " If docetaxel is so powerful, does it's effect way overpower anything else I can do like diet ?" My MO responded that we shouldn't eat processed food. OK, but what about sugar, red meat, even exercise. What do you guys think?

[MooseJawg]

What I’ve read about diet is the Mediterranean gets the highest marks. Eat fresh fruit and veggies (what you can tolerate), some fish, very little red meat, no processed foods.

[Nusch]

From what I gather about your bio, chemotherapy seems like a good option for you. It’s tough—I’ve been through it myself—but it’s also incredibly powerful. Stick with it as long as you can, and focus on recovery afterward.

Exercise and diet are excellent complementary tools, but I wouldn’t consider them a replacement for treatment. Do what you can manage in terms of exercise—your strength will return over time. As for diet, I switched to a plant-based approach with some fish, avoiding processed foods, sugar, and alcohol entirely. It’s been a game-changer for me.

[Doctorsceptic]

my advice is enjoy yourself, eat great food and drink what the hell you want! Carpe diem, life is for living.

If your MO thinks avoiding processed food at our time in life will make the slightest difference he is on another planet.

[alperk in reply to Doctorsceptic]

Thanks. I needed that validation

[smokeyj in reply to alperk]

Yeah, what the hell. Do whatever you want, eat what you want, drink what you want. And don't forget the ho's. Plenty of ho's and drugs. And who needs sleep? Sleep is for wusses. Who cares about a stroke or heart attack? Tomorrow may never come (even though it always has). Is that enough validation for you?

[Hawk56]

My experience, six cycle of Taxotere staring in Jan 17.

With each infusion, the steroids that were administered to prevent nausea thus "throwing up" with the resultant "burns" would results bin a 24-36 hour period after the infusion of "energy." This would be followed by a three to four day crash from the side effects, By the end of the week, I would feel "better" until the next infusion, then repeat.

The side effects were cumulative and hit hard starting with the 4th infusion.

I found that during the 2nd and 3rd weeks after the infusion, I generally felt well enough to live "normally,' I would play basketball, ride my bike, go to the gym, went skiing, travelled to Las Vegas to watch my daughter play in her college team's post season conference tournament...

As to diet, I didn't really change anything. The difference was as I say, the "chemo mouth" where everything generally had a metallic taste. When my wife asked what I would like for dinner, my response was "no offense, but it all tastes the same..."

Still, I generally follow a reasonable diet. We eat lots of fruit vegetables, fish, chicken...That does not mean we restrict ourselves from enjoying BBQ, steaks, Mexican, a drink or two. All things in moderation I say.

Kevin

[alperk in reply to Hawk56]

Great presentation and advice. Thanks for taking the time

[Mgtd]

The best solution is ….

youtu.be/0Xb4kLo4Gp0?si=LKW...(Not working as expected?)

[MateoBeach]

I will not comment on any diet related topics here. But two points about docetaxel chemotherapy: 1) Yes it can kill a lot of cancer cells, but it does not kill ALL of the cancer cells. I do not know of anyone who was cured of advanced PCa by taxol chemo. So your excellent response will require ongoing monitoring and likely require further treatments down the road. (Sorry.)

2) Any treatment for APCa, including chemotherapy and hormonal treatments, if continued long enough continuously, will result in the emergence of resistance through mutations and the therapy will fail. (Sorry again) This has resulted in the emergence of adaptive approaches to treatment where they are stopped before failure and resumed later. Changing it up is an attempt to stay a step ahead of emerging resistance. There are several threads on this site that discuss adaptive therapy approaches and their results.

Another form of adaptive therapy is application of "extinction dynamics" to provide an avenue towards possible cure (extinction of the cancer). This uses a "first strike", such as your chemotherapy, to greatly weaken the cancer and reduce its population. That is where you are now. Then that is stopped and there is a "second strike" of a completely different therapy. This could be Pluvicto radioisotope targeting. Or immunotherapy such as Provenge. Or introducing a new ARSI such as Nubeqa or Abiraterone to ADT. Or all of these rotating in subsequent strikes on the cancer.

IMO you should consider and discuss with your MO (or a new one) NOT just continuing with docetaxel until it fails, but switch it up. You can't just throw fastballs and expect to succeed. MB

[NanoMRI in reply to MateoBeach]

well written!

[j-o-h-n in reply to MateoBeach]

Championship game (all 78,000 fans on their feet):

Your team is leading 1 to nuttin........ top of the of the ninth and 2 out, you're pitching to the ace (mr. Homer with an eye like Ted Williams) with a count of 3 and 2 and bases loaded. You've pitched to mr. Homer 3 times with various pitches in prior at bats during the game. All deep hits and caught right at the warning track. The manager and the third base coaches are looking down at their spikes and refuse to acknowledge or signal you. You're known for your best pitch, which is a fast ball.

Question: Do you wake up or continue sleeping?

Good Luck, Good Health and Good Humor.

j-o-h-n

[Lslal in reply to j-o-h-n]

I’m Canadian so do you have a hockey analogy….lol

[j-o-h-n in reply to Lslal]

Sorry, but I don't have a hockey analogy but just a Factoid about hockey:

There are two reasons why they don't play hockey in the Philippines.

1. There's a shortage of ice skating rings in the Philippines.

2. The Filipinos pronounce the letter "P" like the letter "F".

Good Luck, Good Health and Good Humor.

j-o-h-n

[alperk in reply to j-o-h-n]

😄😄😄

[VictoryPC]

Food. One of the things in this you can control. Spare no expense and enjoy it to the fullest.

[petrig]

Lots of vegetables,hemp oil(!),fiber,broccoli,cauliflower,chicken,wholegrain,lots and lots of drinking water,probiots like yuoghurt,curd/quark,buttermilk. And its good to take Loratadine (non-drowsy antihistamine) daily.