Help; Which treatment for Intraductal with Cribriform? Radiation or Surgery.

[-db123_]

Intraductal with cribriform pattern patient discovered 9/24. 4+3=7, 2 cores grade 4 with 50%, non metastisized, perinural invasion (1 core), 2 cores 3+4=7 5 to 20% grade 4

Possible extracapsular extension.

MD Anderson surgeon ruled Not a candidate for surgery (margins, Extracapsular extension). they suggest Brachytherapy seeds HDR 15 GY, Proton beam 44GY (bead + lymph nodes). Premedicate with Firmagon and ERLEADA (3 months prior)

John's Hopkins surgeon and radiologist both say I am a candidate for surgery or radiation, radiologists suggest same plan as above except using ADT plus Xtiga. (stampeed trial).

Surgeon states I am a fine candidate for surgery, I have a very small prostate however suggests radiation.

My prior urologists said twice to me, your type of cancer does not respond well to radiation.

I have always thought radical.

I could use some help choosing.

Regards

Doug

[GuitarMaker1978]

hi Doug. I’m also 69. I had cribiform, extracapsular extension, and perineural involvement. I also had metastasis to two local lymph nodes. My Gleason score was 9 (4+5). Barnes Jewish Hospital in St. Louis wanted to do nine weeks of IRT then HDR breaking therapy along with two years of first and second generation ADT. For a second opinion, I went to Northwestern medicine in Chicago. their team looked at my PETPSMA scan and MRI as well as my health history and recommended that I have prostatectomy followed by radiation to the pelvic basin and then 18 months of first and second generation ADT. Their team strongly believe that my best chances of a cure lied with removing the cancer mothership, i.e. the prostate, and then working to clean up smaller affected sites. After surgery, my PSA dropped to 0.41. I’m currently in remission and my PSA is on detectable.

Good luck to you on your journey. Don’t hesitate to ask any questions of me.

[-db123_ in reply to GuitarMaker1978]

Did you have Dr. William Catalona?

[j-o-h-n in reply to GuitarMaker1978]

You're not plucking us, are you?

Good Luck, Good Health and Good Humor.

j-o-h-n

[GP24]

Today they use higher doses for radiation, therefore I think you can get radiation. On the other hand possible extracapsular extension means not a great extension. If the surgeon knows where this is located he can cut an extension there. If he did not remove all, you can get salvage radiation. Both treatments can be done.

With all these opinions it is almost impossible for a newly diagnosed patient to decide.