Orgovyx and Zytiga

[Poollover]

Once Orgovyx and Zytiga and Xtandi are no longer stopping my PSA from rising rapidly is there any point to continue taking them. My PSA is doubling every two weeks. It has gone from 0.67 to about 16 in two months. Poollover

[JohnInTheMiddle]

Yikes. May I ask, (1) Zytiga (Abiraterone) ARPI + (2) Xtandi (Enzalutamide) ARA + (3) Orgovyx (Relugolix) ADT all at once?

[Poollover in reply to JohnInTheMiddle]

Switched from Orgovyx and Abi to Orgovyx and Xtandi.

[Tall_Allen]

You have to keep taking Orgovyx. Your androgen receptors have multiplied and are more sensitive than ever to even the slightest bit of testosterone.

You can stop Zytiga (and slowly come off of prednisone) but consider adding docetaxel to Xtandi as in the PRESIDE trial:

prostatecancer.news/2022/10...

[Poollover in reply to Tall_Allen]

Thanks TA, but have not been on the Xtandi for more than a week. I don't want to consider adding docetaxel unless my testosterone starts to go up; currently, it is below 10. So far most of the cancer has resolved and the cancerous prostrate has decreased by about 30%. So far I find the se worse from Xtandi than Abi. Not sure I could handle chemo, 87 years old.

[7OaksTom in reply to Poollover]

Give Xtandi a chance. I had been on Lupron and my PSA nadired at .8. But then it jumped 26-Mar PSA 0.8

26-Apr PSA 1.5

30-May PSA 3.1

18-Jun PSA 5.2

22-Jun Added XTANDI to Lupron

16 Jul PSA .2

16- Aug PSA <0.1

It has remained at <0.1 since then.

[bdrakes in reply to Tall_Allen]

Tall Allen can you help also on advice please regarding Orgovyx. I've recently started post RP into next phase with radiation combined with ADT Orgovyx. I incorporated two med oncologist, one urologist, and one radiation oncologist into the decision process for opinions. You were also instrumental in my moving forward with attacking sooner than later based on gleason, decipher, stage, and Intraductal so thank you kindly for past posts to the many lucky folks out there who access your comments. What is your take on Orgovyx as it appears you're suggesting it's more long-term rather than short term application? I may be reading your comment more than I should but it alarmed me a bit thinking I'll be on it much longer than anticipated. Any insights you have regarding Orgovyx would be greatly appreciated.

[Tall_Allen in reply to bdrakes]

Many men on this site are taking lifelong ADT. You are not.

[bdrakes]

May I ask please how long you’ve been taking Orgovyx ?

Bdrakes

[Mgtd in reply to bdrakes]

I might add why did you switch from say Lupron?

[beogradjanin]

I am 11 years on ADT and 4+ years on Xtandy. Have diagnosed 11 years ago prostate cancer with bones and lymph nodes meta, when my PSA was 155.

During this journey it was coming down and up and finaly rising to 89 in june last year, doubling every 3 months, and then slowling the rise to maximum 105 on the 30th of january this year, than february 75, march 55, april 43, may 32, june, 23, july 14, august 12, september 11,5

I am using this complementary natural method, that I will recomend you, fom july 2023, and be aware that there is time needed to clean your body from toxics and repair imune system (in my case 6-7 months), after the results will be amazing.

I would strongly recomend that, with continuination of your medical therapy, as Ted Alen and others mention, you imidiatelly change your live habbits.

There is no magilal bullet for this cronical illness, so you can not just take the pill and be well and cured. Your earlier life and your bad habits brought the decreasment of your immune system so the cancer was developing and rising.

1. eat only raw plant based food!!!

2. physical exercise or work!!!

3. Spiritual work (prays, meditations...) in order to calm down, relief the fear of death (which will undobthly come to everybody) , liberating your soul, living without stress, controling your ego, passions and fears...!!!!

4. Cleaning your body from!!!:

- parasites (method by Hulda Clark - cloves, pelin, oil from black walnuts)

- cleaning liver (dr Richard Schulze method)

- cleaning bovels (dr Schulze method)

- cleaning kidneys (dr Schulze method)

5. Regular donations to people or animals in need, or the organizations that help them

6. Daily, at least one teaspoon of cayen peper

7. Lot of garlic every day

8. Dry brushing your whole body with natural brush

9. Hot and cold baths or showers (if you can tolerate it, unfortunately I can't)

10. Warming your body (long sleevs and long under pants when temperature is below 20 degrees)

11. Having shower of your body maximum once a month (taking higiene by washing parts separately where and when needed)

12. Stoping using parfumes, deodorants, different creams for body, face, hands, that are full of chemicals.

13. Wearing clothes only from cotton, linen and other natural materials

14. Using Rick Simpson Oil regulary (or smoking indica canabis 2-3 times daily)

15. Having lot of sunbathe and glazing the sun every day

[Poollover]

Thanks for your thoughts and history.

[beogradjanin in reply to Poollover]

I am blessed that I can share my way, and encourage others to do the same, and enjoy every moment of this beautiful life, as I am ❤️