Keytruda for High TMB: Dad’s gene... - Advanced Prostate...

Advanced Prostate Cancer

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Keytruda for High TMB

Justgettingitright profile image

Dad’s gene testing came back and shows high TMB of 20 muts/mb. He also has PDL1 positive in tissue. The MSI status is low at 6%. Attached is the image of the report.

Is he a candidate for Keytruda? The gene report clearly outlines Keytruda as suggested drug.

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Justgettingitright
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10 Replies
Tinkudi profile image
Tinkudi

my dad’s report is very similar to yours. MO said he would be a candidate for Keytruda.

Tall_Allen profile image
Tall_Allen

Why not try it? In India, you might investigate APCEDEN and use it before Keytruda.

Justgettingitright profile image
Justgettingitright in reply toTall_Allen

Hi Tall_Allen we have the APCEDEN vaccine ready. The first dose is to be administered in 2 days. Post that we are given option for either Chemo or Keytruda. Confused as to what might be the best course of action?

Tall_Allen profile image
Tall_Allen in reply toJustgettingitright

Can you do Chemo and Keytruda at around the same time?

Justgettingitright profile image
Justgettingitright in reply toTall_Allen

Will ask the MO about this at our next appointment.

Justgettingitright profile image
Justgettingitright in reply toTall_Allen

Tall_Allen should we get all 6 vaccines of Apceden vaccine and then start Keytruda or we can get the two concurrently in a gap of 3-4 days??

Tall_Allen profile image
Tall_Allen in reply toJustgettingitright

There's no data. But it seems that Apceden starts your immune system working for you and then Keytruda keeps it working, so Apceden followed by Keytruda makes sense to me.

Tinkudi profile image
Tinkudi

did you do the keytruda Justgettingitright hope dad is doing ok

Justgettingitright profile image
Justgettingitright in reply toTinkudi

Hi Tinkudi we have not started Keytruda yet. First chemo and then Keytruda should follow.

Tinkudi profile image
Tinkudi in reply toJustgettingitright

Ok. How is he tolerating the chemo ? Which one ?

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