I have been on Lynparza since June 1, 2024. Had to lower dosage after 3 months to reduce SEs, especially constant fatigue.
Point of this post is supplements. My bone and liver profiles are both ok. But red blood cells are down (Hg) and MCV too high, despite iron in diet. Am considering B12 supplements. I agree with the general need to prefer getting nutrients from diet, but would nevertheless appreciate any comments or suggested alternatives on this case.
lan99, not to worry too much, but a concern. After my radiation, I had a similar situation. Finally my PCP referred me to a hemotologist who did a bone marrow biopsy. Bad news. It was myelodysplastic syndromes with ring sideroblasts (MDS-RS). It is a blood cancer caused by the radiation. It is rare, but I feel way underdiagnoised considering all the co-morbidities we have. Google it.
Thanks. I googled it, is indeed worrying. Not ready for bone marrow biopsy yet but will keep this scenario in mind.
Hello! What kind of radiation that caused blood cancer? Radium 223?
Don't know the answer to your question, but mine was from my SBRT sessions. I would think that any kind of radiation or chemotherapy could cause it. Again, it is rare, but all of us need to know everything we can about this beast.
Been on Lynparza since December 2023. I am currently on half dose until blood work next week. I too suffer from low blood cell count. I have done B12 injections twice a week since February. Doesnt seem to help me. But, may be worth a try
B12 probably won't help. PARP inhibitors interrupt the biochemical mechanism that creates new red blood cells.
Thanks TA. I have the impression it is still early days for Lynparza. Hopefully a more targeted version will be available before long.
TA is there a reason to continue PARPi if it is interrupting bone marrow production? It seems counter intuitive since one will certainly need their bone marrow to produce immune cells.
It has proven to extend survival if men are BRCA+.
My original testing showed no actionable mutations. After castrate resistance, additional testing showed I had acquired BRCA, BRCA2, and ATM. MO was encouraged and started me on Lynparza. I had no blood work side effects; but had some leg cramping and fatigue. Drug is completely ineffective for me, discontinuing and moving on. Her best guess is because they are acquired mutations. Best of luck to others, there is a lot of hope to these drugs.
Interesting. Mine is acquired. This is the first I hear of a possible difference in the effectiveness of the drug in this context.
In trials, half were innate, half acquired. It worked equally well in both. Perhaps the new generation of PARP inhibitors will work better for you, like Module 5 of the trial below:
My oncologist, Dr. Sartor at Mayo warns against B12, he says prostate cancer loves it.
Ed
never heard of the connection between b12 and prostate cancers loving it. Any background info on this subject. I too recently started on lymparza. Psa is dropping steadily since starting but I too see my blood counts dropping as well. I’ve been taking a b complex vitamin and zinc supplements but still see the same side effects. I’ve only been on for 2 months and was hoping the side effects level out a bit. Would love to hear of others experiences with this drug in longer term use. Anybody out there?
No background info, if Sartor tells me not to take it I listen, he is among the top PCa docs in the country.
Ed
I did the first 3 months at full dosage 600mg/day. I was in bed by the end but the PSA dropped 61 to 47. I had to reduce dosage to 400 then 200 before I got some relief. Am unlikely to be getting much benefit from 200/day so need to ramp this up to a level I can tolerate while still getting benefit.
What dosage are you on ?
My PSA was 26. Started on lymparza and was blood tested every week for first 4 weeks. It started to drop in week 4. Today at week 8 PSA is 16.4. Dosage is 400 mg / day. Had a tough time at first with se but has kinda eased up for me. Still fatigue and sweats. Blood work , particularly wbc and rbc counts are low and continue to fall. Anemia is my concern now. I feel good, exercising and eating well. Looking for something in the immunotherapy line that could work for me while I ride this wave. Just had biopsy done. Awaiting results from pathology.
I am stuck taking omeprazole, a stomach acid reducer, for GERD/reflux. For this reason I take B12 supplement sublingually.
Lynparza can be used for treatment when there’s DNA damage. How about without the DNA damage?
Recommendations for additional supplements?
Need some guidelines regarding supplements
I need facts on nutrition, vitamins and supplements.
Book "Let Food be your medicine" by Don Colbert, MD
