Dad was on orgovyx for a couple of months and his Testosterone levels had come down to 26.
Around a month and a half back he added xtandi and the latest T levels came back at 41.
MO said to repeat the T test after a couple of weeks and if it shows an increasing trend to shift to Degarelix or some other ADT.
He has started to take the Relugolix on empty stomach to see if that helps as I read it is absorbed better on an empty stomach.
Has anyone had this happen when they added Xtandi
At the end of my 13-months long ADT vacation, June 5 2024 , my T was at 398 ng/dL (13.8 nmol/L)
I began Orgovyx two days later, on June 7 2024.
By June 26, my T was 28 ng/dL (1.0 nmol/L) and I started Xtandi the following day, June 27 2024.
My latest test was on August 6 2024 and my T was still 28 ng/dL (1.0 nmol/L).
My next test will be on October 16 so we'll see if it is still the same but if I look further back to when I was on Lupron+Abiraterone, most of the time my T was at < 3 ng/dL ( < 0.1 nmol/L) but I see that on one occasion it went up to 9 ng/dL (0.3 nmol/L) and up to 16 ng/dL (0.6 nmol/L) on another.
Looking at my own numbers, I can say that T can fluctuate even while on ADT. I count 8 readings at <3 ng/dL then one at 9 ng/dL then 2 more at <3 ng/dL then one at 16 ng/dL then 1 more at <3 ng/dL. And then I began my ADT vacation so the other readings don't matter in the context of your question.
Hope this helps!
Thanks. So you are saying it can fluctuate. How often do you test T
Why did you change from lupron and Abi to orgovyx and xtandi ? Seems earlier combo was giving lower T levels ?
I test T at the same time as I test PSA, which is pretty much every 1 to 3 months or so, depending on often my MO wants to run tests.
Lupron and Abi were what I was taking pre-vacation. When my vacation ended, my MO suggested that I try some other combo because of how severe the side-effects had been for me on my previous combo. He ended up being right about try this because while I still suffer from the side-effects, they are (at least not yet) as bad this time around.
It's called a T Bump. Normal and at his age not a concern because the DHT conversion is so low.
I know that Lupron creates a T bump initially and Orgovyx does not.
But I am surprised that ARSIs like Xtandi would create a bump since they have to do with receptors and not with the testies. Is it because the body asks the testies to produce more because the receptors are not getting any T?
yes. My t rose from 250 to over 700. Psa went undetectable. When eligard added t went to below detection limit for over 12 months Took eight months foy t to become detectable agsin after discontinuation of adt.
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