Started Talazoparib this week. Anyone else?

[7OaksTom]

My MO started me on Talazoparib (PARP inhibitor for ATM mutation) this week. Anyone else taking this this with Xtandi and 3 month Eligard shots.?

It has the normal scary list of SEs. What have been other's experiences?

[MoonRocket]

Keep us updated on your progress. Some of us on here are ATM mutation positive. Is this part of a clinical trial? Are you actually take the Talzenna formulation?

[7OaksTom in reply to MoonRocket]

Not on a clinical trial. Yes, I am taking the Talzenna formulation.

[Tall_Allen]

Although it is approved for the ATM mutation, it really only works well for men who have the BRCA mutation. And it is very toxic:

prostatecancer.news/2019/10...

I suggest you enroll in the following clinical trial of a second generation PARP inhibitor. In early trials, it seems they may be beneficial against ATM+ and they are quite a bit less toxic. Module 5 accepts men in your category:

clinicaltrials.gov/study/NC...